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2014 Fiscal Year Final Research Report

Analysis of Epstein-Barr virus (EBV)-infected T cells in EBV associated hemophagocytic lymphohistiocytosis

Research Project

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Project/Area Number 24591542
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKanazawa University

Principal Investigator

WADA Taizo  金沢大学, 大学病院, 講師 (30313646)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords小児科学 / EBウイルス / 血球貪食性リンパ組織球症
Outline of Final Research Achievements

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is characterized by ectopic EBV infection in CD8+ T cells and their clonal proliferation. We demonstrate that EBV-infected cells can be detected as highly activated CD5-/dim CD8+ T cells that often react with a specific TCR Vβ monoclonal antibody in patients with EBV-HLH, who exhibit characteristic profiles of serum cytokines. Although down-regulation of CD5 in CD8+ T cells is not specific for EBV-HLH, the combined approach of our flow cytometric analysis including TCR Vβ repertoire and cytokine profile analysis may be useful in diagnosis and follow-up of patients with EBV-HLH.

Free Research Field

医師薬学

URL: 

Published: 2016-06-03  

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