Study on the therapeutic strategy for acyclovir-resistant HSV-1 infections in neonate

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591591
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: SAIJO MASAYUKI 国立感染症研究所, その他部局等, その他 (50300926)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 新生児ヘルペス / ヘルペス脳炎 / 薬剤耐性 / 単純ヘルペスウイルス1型 / アシクロビル

Outline of Final Research Achievements

The neonatal herpes with encephalitis, which was resistance to acyclovir (ACV) therapy, was virologically confirmed to be caused by ACV-resistant herpes simplex virus type 1 (HSV-1) in this study for the first time. DNA polymerase-associated ACV-resistant HSV-1 was generated by selection of the HSV-1 with S2242. Most of the viruses were sensitive or hypersensitive to ganciclovir, while they were cross-resistant to foscarnet. In recent years, the number of patients with immunodeficiency including those who received organ transplantation, suggesting that drug-resistant HSV-1 infections might become a great concern. The diagnostic system including the sensitivity assay and effective therapeutic strategies should be prepared in advance.

Free Research Field

ウイルス感染症，小児科学，感染症学