2014 Fiscal Year Final Research Report
The association between chorein and mitochondria-related cell death
Project/Area Number |
24591685
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kagoshima University |
Principal Investigator |
NAKAMURA Masayuki 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90332832)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 有棘赤血球舞踏病 / chorein / オートファジー / マイトファジー |
Outline of Final Research Achievements |
Co-immunoprecipitation assay and immunocytochemical analysis using chorein-overexpressing cells showed interaction between chorein and cytoskeltal proteins and autophagy-related proteins. The chorein-cytosleltal proteins iteraction was increased in CCCP-treated cells. Cell viability was significantly increased in chorein-overexpressing cells compared with mock transfected control cells during nutrient deprivation and during CCCP treatment. These results suggest that chorein interacts with cytoskeltal proteins and autophagy-related proteins and may play protective roles in cell death mediated by autophagy- and mitophagy-related mechanisms. Their disruption may be one of the molecular pathogenic mechanisms of chorea-acanthocytosis.
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Free Research Field |
精神神経医学
|