2014 Fiscal Year Final Research Report
Study of the glutamate excitotoxicity in the hippocampus with Alzheimer's disease
| Project/Area Number |
24591697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アルツハイマー病 / 神経細胞変性 / 神経科学 / 認知症 |
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| Outline of Final Research Achievements |
The postmortem study examined immunohistochemical localization and distribution of ubiquilin (UBL) and butyrylcholinesterase (BChE), in the hippocampus from Alzheimer’s disease (AD) dementia cases. All Braak III-IV and the majority of Braak V-VI AD cases had markedly increased UBL immunoreactivity in the nucleoplasm of CA2/3, CA4, and dentate granular neurons. Compared to controls, AD cases had greater BChE immunoreactivity in hippocampal neurons and neuropil, most prominently in CA2/3 pyramidal neurons and stratum oriens. These results suggest that the prominent upregulation of ubiquilin and BChE activity in CA2/3, the region generally considered more resistant to pathology, could reflect a novel compensatory mechanism.
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| Free Research Field |
老年精神医学
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