2014 Fiscal Year Final Research Report
Prediction of late rectal bleeding treated with radiotherapy for prostate cancer using biochemical marker.
Project/Area Number |
24591846
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Sapporo Medical University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 放射線直腸炎 / 前立腺癌 / 放射線治療 / 有害事象予測 |
Outline of Final Research Achievements |
To predict individual radiosensitivity of normal tissue, we collected and analysed the expressions of Ku80 mRNA and radiation-induced microRNA-99a in peripheral blood lymphocytes treated with radiotherapy for prostate cancer. Peripheral blood lymphocytes were collected from 97 prostate cancer patients with at least 3 year of follow-up after radiotherapy. As a result, a combination of low Ku80 mRNA expression and highly-induced microRNA-99a could precisely detect grade 2 or more of radiation-induced late rectal bleeding. In conclusion, a combination of low Ku80 expression and highly-induced microRNA-99a expression could be a promising marker for predicting rectal bleeding after radiotherapy.
|
Free Research Field |
放射線腫瘍学
|