Development of a novel drug delivery system for the treatment of peritoneal dissemination of gastric cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591941
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: OBAMA Kazutaka 京都大学, 医学(系)研究科(研究院), 非常勤講師 (50322649)
• Co-Investigator(Kenkyū-buntansha): SAKAI Yoshiharu 京都大学, 医学研究科(研究院), 教授 (60273455) ; TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ドラッグデリバリーシステム / ゼラチン / 徐放剤 / 腹膜播種

Outline of Final Research Achievements

The main purpose of this study was to develop a new delivery system for intraperitoneal administration of anti-cancer agents (ACA) against peritoneal dissemination that can reduce systemic toxicity and achieve high dose chemotherapy. As a carrier of ACAs, microspheres were prepared from gelatin of a non-toxic and biodegradable material for the sustained release of CDDP. The gelatin hydrogel microspheres incorporating CDDP (GM-CDDP) were able to release CDDP in the peritoneal cavity as a result of gelatin biodegradation. GM-CDDP was injected intraperitoneally into a mouse model of a peritoneal dissemination; their therapeutic efficacy and adverse effects were evaluated. Gelatin hydrogel microspheres decreased the adverse effects of CDDP and allowed high dose intraperitoneal chemotherapy for peritoneal dissemination of cancer cells due to controlled CDDP release. Currently, we are performing experiments for optimization of this carrier of ACAs for better clinical applications.

Free Research Field

胃癌治療