Expression and role of the novel angiogenic regulatory factor Vasohibin-1 in the carotid atherosclerotic plaques

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: YOSHIDA Kazumichi 京都大学, 医学(系)研究科(研究院), 講師 (90598921)
• Co-Investigator(Kenkyū-buntansha): ARAI Hidenori 京都大学, 医学(系)研究科(研究院), 教授 (60232021)
• Co-Investigator(Renkei-kenkyūsha): OKADA Tomohisa 京都大学, 医学(系)研究科(研究院), 講師 (30321607) ; SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779) ; TAKAGI Yasushi 京都大学, 医学(系)研究科(研究院), 准教授 (40312227)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 動脈硬化 / 不安定プラーク / 頚動脈狭窄 / プラーク内出血 / 血管新生調節因子 / バソヒビン

Outline of Final Research Achievements

It was demonstrated in this study that the expression level of novel angiogenic regulatory factor Vasohibin-1 was significantly higher in carotid atherosclerotic plaque than normal vascular endothelium. There was also significant positive correlation in the expression level between Vasohobin-1 and atherosclerosis-related inflammation markers such as ICAM-1 and VCAM-1. Immunohistochemical investigation revealed that Vasohibin-1 was predominantly expressed in the neovascular endothelium of carotid plaques. These findings strongly suggested the contribution of Vasohibin-1 in the destabilization mechanism of carotid atherosclerosis.

Free Research Field

脳神経外科学