OPLL model mouse and mechanisms-de-ubiquitination leads to a posterior longitudinal ligament ossification breakthrough in proteomics

2016 Fiscal Year Final Research Report

• Project/Area Number: 24592215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kurume University
• Principal Investigator: Tsuru Michiyo 久留米大学, 疾患プロテオミクス遺伝子治療, 講師 (90368887)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: 難病克服研究 / 後縦靭帯骨化症 / モデルマウス / プロテオミクス / 医薬品開発

Outline of Final Research Achievements

In our nation, there are roughly 300 intractable diseases identified by the Ministry of Health, Labour and Welfare. Our study focuses on just one of these diseases; however, I am confident that it represents a breakthrough in our understanding of diseases whose causes were previously unknown. I strongly believe that our research method, proteomics, has much to offer in the fight against intractable diseases. I have devoted 15 years to demonstrating my theory through the identification and purification of disease-specific proteins, and the establishment of mouse models for such. This study has the potential to stamp out intractable diseases around the world; it is what researchers and patients alike have been hoping for.

Free Research Field

疾患プロテオミクス