2014 Fiscal Year Final Research Report
Treatment strategy for circulating tumor cell using telomerase activity with epithelial-mesenchymal transition
| Project/Area Number |
24592381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONAKA Hiroyuki 金沢大学, 大学病院, 講師 (40334768)
KYO Satoru 島根大学, 医学部, 教授 (50272969)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 泌尿器癌 / テロメラーゼ / 血管内浮遊癌細胞 |
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| Outline of Final Research Achievements |
Novel adenovirus vector with human telomerase reverse transcriptase (hTERT) promoter could be constructed. In vitro, renal cancer cells (ACHN) and prostate cancer cells (PC3, LNCaP, DU145) were detected in human blood using this vector, however, 100 to 1000 cells were needed to detect in 1 ml of human blood, which was insufficient for the clinical practice. In vivo, circulating tumor cells could not be detected in the human blood samples of 30 patients with urological cancers (10 renal cell carcinoma, 12 urothelial carcinoma, 8 prostate cancer).
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| Free Research Field |
泌尿器科
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