The relationship between the metabolic syndrome and presbycusis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592551
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Yamaguchi University
• Principal Investigator: YAMASHITA Hiroshi 山口大学, 医学(系)研究科(研究院), 教授 (00210419)
• Co-Investigator(Kenkyū-buntansha): SHIMOGORI Hiroaki 山口大学, 大学院医学系研究科, 准教授 (70226273) ; SUGAHARA Kazuma 山口大学, 医学部附属病院, 講師 (20346555) ; HIROSE Yoshinobu 山口大学, 医学部附属病院, 助教 (80555714)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 内耳 / メタボリックシンドローム / 老化 / 難聴

Outline of Final Research Achievements

This purpose of this study is to elucidate the relationship between the metabolic syndrome and presbycusis. The study was conducted using a model mouse TSOD for metabolic syndrome.
The results showed that the hearing function of metabolic syndrome animal models decreased earlier than that of control animals. The histopathological examination showed arteriosclerosis in the blood vessels of the inner ear. In addition, the microarray analysis of expressed genes indicated the attenuation of many kinds of growth factors. These results can contribute to the development of the prevention methods for presbycusis related with metabolic syndrome.

Free Research Field

耳鼻咽喉科学