2014 Fiscal Year Final Research Report
Functional analysis of Hippo signaling pathway during salivary gland development in mice.
| Project/Area Number |
24592768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 唾液腺 / 発生 / シグナル伝達 |
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| Outline of Final Research Achievements |
The aim of this study is to clarify the role of Hippo signal transduction pathway for cell growth and maintenance of luminal structure in mouse salivary gland tissue. The analysis of gene expression of Hippo factors showed that transcription co-factor Yap protein localized in different manner between embryo and adult salivary gland cells. Inhibition of Yap protein translation decreased growth of salivary gland tissue and branching of epithelium in tissue culture system. The results suggest that Yap has an important role in growth of salivary gland tissue.
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| Free Research Field |
分子生物学
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