Molecular characterization of the pathogenic factors of oral streptococci involved in autoimmune disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592833
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: The University of Tokushima
• Principal Investigator: HIROTA Katsuhiko 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (60199130)
• Co-Investigator(Kenkyū-buntansha): MIYAKE Yoichiro 徳島大学, 大学院ヘルスバイオサイエンス, 教授 (80136093) ; MURAKAMI Keiji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (10335804) ; OKAMURA Hirohiko 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20380024)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PAMPs / 自己免疫疾患 / バイオフィルム / IP-10 / CCL2 / CCL4 / ケモカイン

Outline of Final Research Achievements

Using genome microarray to define the gene expression profile of rSi-HLP-stimulated THP-1 cells, 83 genes were up-regulated (two fold higher) among 28,869 genes profiled. Especially, genes coding for chemokines and pro-inflammatory cytokines, such as CCL2, 3, 4, CXCL8, 10 were the most highly up-regulated groups. Recombinant Streptococcus intermedius histone-like DNA binding protein is one of the set Inducer excessive CXCL10, CXCL 8, CCL2, CCL3, CCL4 from human THP-1 cells.

Free Research Field

細菌学