Analysis of a balance between pro-inflammatory and anti-inflammatory pulpal responses in the pathogenesis of pulpitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: NAKANISHI Tadashi 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (00217770)
• Co-Investigator(Kenkyū-buntansha): YUMOTO Hiromichi 徳島大学, 病院, 講師 (60284303) ; HOSOKAWA Yoshitaka 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (90346601)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 歯髄炎 / 歯髄細胞 / サイトカイン

Outline of Final Research Achievements

With advance of dental caries, the infiltration of effecter T cells and the production of various inflammatory mediators such as prostaglandin (PG) in the dental pulp tissue become apparent. In this study, we evaluated the role of a balance between pro-inflammatory and anti-inflammatory responses in the pathogenesis of pulpitis using dental pulp cells. As a result, interleukin-17 from effecter T cells induced the production of cytokines such as CXCL10 and CCL20 in the dental pulp cells. In contrast, PGF2α up-regulated CCL20 production and down-regulated CXCL10 production in the activated dental pulp cells.

Free Research Field

歯内治療学