Selective ligand of dopamine receptor subtype gives to anesthetic action.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: OGAWA Yoshitaka 広島大学, 医歯薬保健学研究院, 助教 (10294597)
• Co-Investigator(Kenkyū-buntansha): IRIFUNE Masahiro 広島大学, 大学院医歯薬保健学研究院(歯), 教授 (10176521) ; MORITA Katsuya 広島文化学園大学, 看護学部, 教授 (10116684)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 全身麻酔 / ドパミン / 正向反射 / 不動化

Outline of Final Research Achievements

We examined the alteration in dopamine neurons of the central nervous system after noxious stimulation during sedation or general anesthesia induced by pentobarbital. The noxious stimulation under pentobarbital sedation increased dopamine release in the nucleus accumbens, but decreased in the striatum. Pentobarbital anesthesia also decreased dopamine release both in the nucleus accumbens and striatum. The dopamine re-uptake inhibitor GBR-12909 significantly increased dopamine concentration in the nucleus accumbens, and reversed pentobarbital sedation. On the contrary, the depletion of dopamine induced by reserpine enhanced pentobarbital anesthetic effects. These results suggest that stimulation of dopamine neurons has a relationship to arousal, and depression of dopamine neurons has a relation to enhancement of anesthesia.

Free Research Field

歯科麻酔学