Elucidation of molecular mechanisms in pain-emotion system for chronic pain and applicatiopn of BDNF treatment

2014 Fiscal Year Final Research Report

• Project/Area Number: 24593057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yamaguchi University
• Principal Investigator: ISHIKAWA Toshizo 山口大学, 医学(系)研究科(研究院), 教授 (90034991)
• Co-Investigator(Kenkyū-buntansha): NAKANISHI Osamu 九州歯科大学, 歯学部, 名誉教授 (50137345) ; KAKEDA Takahiro 川崎医療福祉大学, 医療福祉学部, 准教授 (60403664) ; YAMAMOTO Misa 山口大学, 大学院医学系研究科, 講師 (70379957) ; FURUKAWA Shoei 岐阜薬科大学, 薬学部, 教授 (90159129) ; IBUKI Takae 京都府立医科大学, 大学院医学研究科, 講師 (90232587) ; TOKUDA Nobuko 山口大学, 大学院医学系研究科, 教授 (70227578) ; ISHIKAWA Kouzou 北海道大学, 遺伝子病制御研究所, その他 (20624795) ; SUZUKI Hidenori 山口大学, 大学院医学系研究科, 助教 (30393432)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 慢性疼痛 / 気分障害 / 神経栄養因子 / pERK / カテコール化合物 / magnetic stimulation

Outline of Final Research Achievements

Depression-like behavior is often complicated by chronic pain. However, little is known about neurotrophic factor(BDNF) mediated preventing effect on mood disorder in chronic pain and its molecular mechanisms. We aimed to investigate the effects of magnetic field stimulation(MFS) and 4-methycatechol(4-MC) based on brain-derived neurotrophic factor (BDNF)-mediated signaling and gene expression in chronic pain. Both MFS and 4-MC ameliorated chronic pain and pain-related negative emotion by normalizing the induction of BDNF . These results suggest that MFS and 4-MC may represent the additional strategies against chronic pain associated with depression.

Free Research Field

痛みの分子機構