The application of central analgesic activity of chemical derivatives of gamma-aminobutyric acid (GABA) to general anesthesia -the growing out of narcotic-dependent anesthesia-

2015 Fiscal Year Final Research Report

• Project/Area Number: 24593058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: ITO SHINICHI 九州大学, 歯学研究科(研究院), 助教 (00315095)
• Research Collaborator: KARUBE Noriko
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: GABA誘導体 / 全身麻酔 / シナプス前神経終末部 / 神経伝達物質 / 中枢神経系 / プレガバリン / ガバペンチン / プロポフォール

Outline of Final Research Achievements

We examined the sedative effects of pregabalin on the intravenous sedation (IVS) using propofol. The propofol CTs at the BIS values of 60-80 were significantly reduced in the pregabalin group. The propofol CTs were significantly lowered at Ramsay’s sedation score 3-6 in the pregabalin group. We conclude that oral premedication of pregabalin reduced the amount of propofol to obtain acceptable and adequate sedation level.
We investigated the effects of propofol on the glutamate-induced increase in [Ca2+]pre in the presynaptic boutons of hippocampal CA1 pyramidal neurons. Propofol dose-dependently suppressed glutamate-induced increase in [Ca2+]pre in boutons attached to dendrites, but not to the soma or base of the dendritic tree. Propofol may possibly have some effect on glutamate-regulated neurotransmitter release from excitatory presynaptic nerve terminals through inhibiting the increase in [Ca2+]pre induced by glutamate.

Free Research Field

歯科麻酔学