2014 Fiscal Year Final Research Report
Involvement of the Warburg effect in the regulation of ccn2 gene expression
| Project/Area Number |
24593060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
KONDO Seiji 昭和大学, 歯学部, 准教授 (10432634)
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| Co-Investigator(Kenkyū-buntansha) |
KAMATANI Takaaki 昭和大学, 歯学部, 助教 (00315003)
MUKUDAI Yoshiki 昭和大学, 歯学部, 助教 (50325099)
KURIHARA Yuji 昭和大学, 歯学部, 助教 (90514969)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 低酸素 |
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| Outline of Final Research Achievements |
A novel GAPDH-mediated gene regulatory mechanism controlling the stability of ccn2 mRNA during hypoxia is uncovered. The precise regulatory mechanism of the degradation of ccn2 mRNA by the interaction among the ccn2 3'-UTR and GAPDH was identified. The observed redox regulation would supposedly be important for switching ccn2 gene expression upon the exposure to hypoxic or oxidative stress.
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| Free Research Field |
口腔外科
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