Analysis of bone metabolism in micro- and hypergravity using a novel hard-tissue model

2014 Fiscal Year Final Research Report

• Project/Area Number: 24620004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 宇宙生命学
• Research Institution: Kanazawa University
• Principal Investigator: SUZUKI Nobuo 金沢大学, 環日本海域環境研究センター, 准教授 (60242476)
• Co-Investigator(Kenkyū-buntansha): KITAMURA Kei-Ichirou 金沢大学, 保健学系, 教授 (80283117) ; HATTORI Atsuhiko 東京医科歯科大学, 教養部, 教授 (70183901) ; IKEGAME Mika 岡山大学, 医歯(薬)学総合研究科, 准教授 (70282986) ; OMORI Katsunori 亜細亜大学, 経済学部, 教授 (20358534)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 微小重力 / 過重力 / 骨芽細胞 / 破骨細胞 / 魚類のウロコ

Outline of Final Research Achievements

Because there is no suitable in vitro assay system, the detailed mechanism of bone resorption and formation in gravity has not yet been elucidated. Therefore, we have developed an in vitro assay system and examined bone metabolism using a fish scale that contains osteoblasts and osteoclasts in the calcified tissue. As a result, the scale sensitively responded to gravity. It became clear that this occurred not only at the gene level but also caused morphologic change. This result appears to provide the knowledge that elucidates the mechanism for this response to gravity.

Free Research Field

宇宙生物科学