Effectiveness of noise-like vibration loading in preventing osteoporosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650265
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: TAKESHI Matsumoto 大阪大学, 基礎工学研究科, 准教授 (30249560)
• Co-Investigator(Kenkyū-buntansha): SERA Toshihiro 九州大学, 工学系研究員, 准教授 (40373526)
• Co-Investigator(Renkei-kenkyūsha): UESUGI Kentaro 高輝度光科学研究センター, 研究員 (80344399)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨粗鬆症 / 全身性微振動刺激 / ランダム性

Outline of Final Research Achievements

Whole body vibration (WBV) has the anabolic effects. In this study, we examined the effectiveness of noise-like vibration in preventing bone atrophy under disuse conditions and in promoting bone defect repair under estrogen-deficient conditions using mouse models. Noise-like WBV reduced the disuse-induced loss of cancellous bone compared with sine WBV and enlarged the medullary space without affecting cortical thickness. There was no effect of noise-like WBV on the amount of bone formation in defect repair; however, it increased the elastic modulus of regenerated bone. Furthermore, with concurrent use of parathyroid hormone, the new bone hardness became elevated. These results suggest the noise-like vibrational mode is favorable for enhancing the anabolic effect of WBV.

Free Research Field

生体医工学