2014 Fiscal Year Final Research Report
Age-related bladder dysfunction and early drug treatment
| Project/Area Number |
24650321
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Research Collaborator |
OSHIRO Takuma
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 加齢 / 低活動膀胱 / 過活動膀胱 / ギャップ結合 |
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| Outline of Final Research Achievements |
To confirm the mechanisms of age-associated detrusor underactivity (DU), we examined the differences in bladder activity and connexin-43 (Cx43)-derived gap junctions in the bladders of young and old rats. Cystometric evaluations revealed that compared with young rats, bladder contractility was reduced by 27% and residual urine volume was significantly increased in old rats. Under isovolumetric conditions, bladder contraction was suppressed after the intravesical application of carbenoxolone. In the bladders of old rats, increase of smooth muscle cell hypertrophy and fibrous tissue was observed compared with young rats. In association with these findings, immunostaining for smooth muscle Cx43 and its protein level were decreased by 28% compared with young rats. These results suggest that age-related DU might be caused by the downregulation of gap junctional intercellular communication in the bladder.
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| Free Research Field |
神経泌尿器科
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