2013 Fiscal Year Final Research Report
Identification of a genetic polymorphism that can predict the effects of resistance exercise training for the prevention of sarcopenia
| Project/Area Number |
24650331
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Juntendo University (2013)
Tokai University (2012) |
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Principal Investigator |
MACHIDA Shuichi 順天堂大学, スポーツ健康科学研究科, 准教授 (40421226)
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| Co-Investigator(Kenkyū-buntansha) |
FUKU Noriyuki 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40392526)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Masashi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60155166)
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| Project Period (FY) |
2012-04-01 – 2013-03-31
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| Keywords | サルコペニア / 遺伝子多型 / 筋力トレーニング / 骨格筋量 |
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| Research Abstract |
Sarcopenia is characterized by a progressive decrease of skeletal muscle mass and function (strength or performance) with aging. Sarcopenia has become a highly significant public health problem, physical disability, metabolic syndrome and cardiovascular diseases. Resistance exercise training is well established as the most effective non-pharmacological intervention to restrict or prevent sarcopenia. However, previous studies observed enormous inter-individual variability in muscle mass and strength. Inter-individual variations for muscle mass and strength may be due to environmental factors, genetic factors and/or gene-environment interactions. Here we tried to identify genetic polymorphisms associated with trainability of skeletal muscle mass after resistance exercise training in elderly Japanese people with low relative skeletal muscle mass.
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[Journal Article] The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts2014
Author(s)
Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A
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Journal Title
Age
Volume: 36
Pages: 933-43
DOI
Peer Reviewed
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes2013
Author(s)
Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M
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Journal Title
BMC Genomics
Volume: 14
Pages: 248
DOI
Peer Reviewed
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[Journal Article] Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases2013
Author(s)
Zhou H, Mori S, Kou I, Fuku N, Naka Mieno M, Honma N, Arai T, Sawabe M, Tanaka M, Ikegawa S, Ito H
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Journal Title
J Hum Genet
Volume: 58
Pages: 109-12
DOI
Peer Reviewed
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