Molecular mechanisms of site-related differences of sarcopenia in Japanese women

2014 Fiscal Year Final Research Report

• Project/Area Number: 24650342
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
• Principal Investigator: TANAKA Nobuho 独立行政法人国立病院機構(相模原病院臨床研究センター), 政策医療企画部, 研究員 (60530920)
• Co-Investigator(Kenkyū-buntansha): FUKUI Naoshi 東京大学, 大学院総合文化研究科, 教授 (10251258) ; YAMAGUCHI Tetsuo 徳島大学, 大学院ソシオ・アーツ・アンド・サイエンス研究部, 准教授 (80569731)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: サルコペニア / 加齢 / 部位 / 分子基盤

Outline of Final Research Achievements

We used cDNA microarray analysis to identify the genes, which is related to a site-specific loss of skeletal muscle mass. We analyzed the data of quadriceps and hamstrings in young as well as aged women. We then focused on genes wherein the expression is increased in aged group. We identified twenty genes, which had higher expression in aged-quadriceps compared to aged-hamstrings. Ten pathways were found which may have caused to the aging of the quadriceps.

Free Research Field

分子生物学