2013 Fiscal Year Final Research Report
Pectin can be sources of methanol by fermentation in the large intestine.
| Project/Area Number |
24650491
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nayoro City University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ペクチン / メタノール / 大腸内発酵 / 腸内細菌 / ギ酸 / 大腸 |
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| Research Abstract |
To determine whether methanol is released by fermentation of low- and high-methoxy pectin in the large intestine, and then supplied in the body, we examined the change in released methanol into the bloodstream and plasma formate concentration in rats fed different degree of methylation of pectin. Methanol was released from methoxy pectins in the large intestine and methanol concentration in portal and arterial plasma was significantly higher in rats fed pectin. The release could be attributed to degradation of pectin by Escherichia coli. Also, the released content of methanol was higher in rats fed high-methoxy pectin than in those fed low-methoxy pectin. Higher plasma formate concentration was observed in rats fed high-methoxy pectin. Taken together, methanol is supplied in the body by fermentation of pectin in the large intestine.
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