2013 Fiscal Year Final Research Report
Catalytic Asymmetric Synthesis of Chiral Transition-Metal Complexes by the Use of Modern Organic Transformation
| Project/Area Number |
24655039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Inorganic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 有機金属化学 / 触媒的不斉合成 / 均一系触媒 / 面不斉 / メタロセン / アレーンクロム / メタセシス |
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| Research Abstract |
Kinetic resolution of 1,2-diallylferrocene derivatives by Mo-catalyzed asymmetric ring-closing metathesis (ARCM) gave the corresponding (4,7-dihydroindenyl)iron(II) derivatives in good yields with high enantioselectivity. In the same way, desymmetrization of (1,2,3-triallylindenyl)-metallocenes by ARCM provided the corresponding (1,4-dihydrofluorenyl)-metallocene derivatives in high ee's.
The Cs-symmetric zirconocenes could be converted to the corresponding C3-bridged planar-chiral ansa-zirconocenes by ARCM with high enantioselectivity. The obtained planar-chiral ansa-zirconocene complexes could be applicable to the asymmetric carbometallation reaction as catalysts.
Kinetic resolution of the racemic planar-chiral (arene)chromium complexes was realized by Mo-catalyzed ARCM with excellent enantioselectivity. The optically active (bromoarene)chromium complex thus obtained is an excellent precursor to various planar-chiral (arene)chromium complexes.
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Research Products
(22 results)
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[Journal Article] Atropisomeric Chiral Dienes in Asymmetric Catalysis : C_2-Symmetric (Z,Z)-2,3-Bis[1-(di- phenylphosphinyl)ethylidene]tetralin as Highly Active Lewis-Base Organocatalyst2013
Author(s)
Ogasawara, M.; Kotani, S.; Nakajima, H.; Furusho, H.; Miyasaka, M.; Shimoda, Y.; Wu, W.-Y.; Sugiura, M.; Takahashi, T.; Nakajima, M
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Journal Title
Angew. Chem. Int. Ed.
Volume: 52
Pages: 13798-13802
DOI
Peer Reviewed
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[Journal Article] Asymmetric Aldol Reaction on Water using an Organocatalyst Tethered on a Thermoresponsive Block Copolymer2013
Author(s)
Suzuki, N.; Inoue, T.; Asada, T.; Akebi, R. Kobayashi, G.; Rikukawa, M.; Masuyama, Y.; Ogasawara, M.; Takahashi, T.; Thang, S
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Journal Title
Chem. Lett.
Volume: 42
Pages: 1493-1495
DOI
Peer Reviewed
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[Presentation]2012
Author(s)
Ogasawara, M
Organizer
Visiting Lecturer of the Chemistry Research Promotion Center (Taiwan)
Place of Presentation
National Science Council, Taiwan
Year and Date
20121224-28
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