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2013 Fiscal Year Final Research Report

The regulation of energy metabolism by brown-adipokine

Research Project

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Project/Area Number 24659113
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKanazawa University

Principal Investigator

HINOI Eiichi  金沢大学, 薬学系, 准教授 (70360865)

Co-Investigator(Renkei-kenkyūsha) SAKURAI Takeshi  金沢大学, 医学系, 教授 (60251055)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsbrown adipocyte / obesity / energy expenditure
Research Abstract

Although the growth differentiate factor 5 (GDF5) has been implicated in skeletal development in mammal, little attention has been paid to the functionality in adipogenesis and energy homeostasis. Here, we show a critical role of the GDF5 in regulating both brown adipogenesis and whole-body energy expenditure. Transgenic mice overexpressing GDF5 in adipose tissues not only showed a lean phenotype but protection against high fat diet-induced obesity due to increased energy expenditure. On the contrary, mutant mice harboring dominant-negative form of GDF5 have impaired energy expenditure and thermogenesis on obesogenic condition. GDF5 activated brown adipogenesis through bone morphological protein receptor (BMPR) pathway. Taken together, these findings demonstrate that GDF5/BMPR pathway regulates brown adipogenesis and energy homeostasis and suggest that modulation of this pathway might be a plausible strategy for obesity and metabolic dysfunctions.

  • Research Products

    (5 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure2014

    • Author(s)
      Hinoi, E., Nakamura, Y., Takada, S., Fujita, H., Iezaki, T., Hashizume, S., Takahashi, S., Odaka, Y., Watanabe, T. and Yoneda Y
    • Journal Title

      Diabetes

      Volume: 63 Pages: 162-75

    • DOI

      10.2337/db13-0808

    • Peer Reviewed
  • [Journal Article] Repression of adipogenesis through promotion of Wnt/ß-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia2013

    • Author(s)
      Nakamura, Y., Hinoi, E., Iezaki, T., Takada, S., Hashizume, S., Takahata, Y., Tsuruta, E., Takahashi, S. and Yoneda, Y
    • Journal Title

      Biochim. Biophys. Acta. Mol. Basis Dis.

      Volume: 1832 Pages: 1117-28

    • DOI

      10.1016/j.bbadis.2013.03.010

    • Peer Reviewed
  • [Journal Article] The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin2012

    • Author(s)
      Hinoi, E., Nakatani, E., Yamamoto, T., Iezaki, T., Takahata, Y., Fujita, H., Ishiura, R., Takamori, M. and Yoneda, Y
    • Journal Title

      J. Bone Miner. Res.

      Volume: 27 Pages: 2526-34

    • DOI

      10.1002/jbmr.1708

    • Peer Reviewed
  • [Presentation] 骨組織による糖代謝調節機構2012

    • Author(s)
      檜井栄一
    • Organizer
      第1回糖尿病と新しい合併症を考える会~糖尿病と骨~
    • Place of Presentation
      京成ホテルミラマーレ(千葉県)
    • Year and Date
      2012-09-07
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~yakubutu/index.html

URL: 

Published: 2015-06-25  

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