Mechanism of carcinogenesis by bacterial pathogenic factor

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659120
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Hokkaido University
• Principal Investigator: HIGASHI Hideaki 北海道大学, 人獣共通感染症リサーチセンター, 教授 (20311227)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 細菌 / タンパク質リン酸化

Outline of Final Research Achievements

As infection with intestinal residential bacteria depends on the host immune system and induces tumor formation, bacterial infection was predicted to be a potential risk factor of carcinogenesis, as is the case for oncoviral infection. The aim of this study was to reveal the effect of bacterial infection on cell proliferation through the functional analysis of Tarp molecules in Chlamydia trachomatis. We created a humanized C. trachomatis tarp gene and successfully constructed a system for ectopic Tarp expression in animal cells, which has been considered difficult thus far. We also studied an approach to create genetically modified animals using the humanized genes.

Free Research Field

分子生物学