びまん性冠動脈病変に対する血管ならびに脂肪組織移植による革新的血行再建法の開発

2012 Fiscal Year Annual Research Report

• Project/Area Number: 24659392
• Research Institution: The University of Tokushima
• Principal Investigator: 佐田 政隆 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80345214)
• Project Period (FY): 2012-04-01 – 2013-03-31
• Keywords: 動脈硬化 / バイパス手術 / 脂肪組織 / 血管形成術 / 血行再建 / 慢性炎症

Research Abstract

糖尿病などを原疾患としてびまん性冠動脈病変を発症し、従来の血管形成術やバイパス手術では血行再建が不可能である症例が増加している。このような症例は、現在のところ心移植しか有効な治療法はないが、日本においてはドナーが絶対的に不足している。このような症例に対して、内胸動脈などを移植することで新規に冠動脈を形成すると同時に病変部周囲脂肪組織を置換して動脈硬化に強い環境を創出する革新的血行再建法の開発を目的にした。
まず、ヒトびまん性冠動脈疾患の病態生理を明らかにするために、on lay patch 法と呼ばれる、「びまん性冠動脈病変の内膜摘出し、自己内胸動脈を摘出冠動脈の天井部分にパッチとして冠動脈を形成する手術」によって得られるサンプルを組織学的に観察した。びまん性病変の病態においては、血管壁における増強した慢性炎症を基盤としており、そこには、マクロファージやTリンパ球の浸潤が認められ、病変内血管新生が亢進していることが明らかとなった。また、慢性炎症は血管壁のみでなく、冠動脈を覆う心臓周囲脂肪組織にも波及していた。
さらにマウス大腿動脈のワイヤー傷害モデルにおいて、周囲脂肪組織が病変形成に及ぼす影響を検討した。痩せたマウスの皮下脂肪移植では病変形成が抑制され、肥満マウスの内臓脂肪移植では病変形成が促進することがわかった。また、アディポネクチンの発現低下と炎症性サイトカインの発現亢進が、病変形成促進作用に関与していることが明らかとなった。
以上の基礎的な裏付けをもとに、「従来の技術では血行再建不能なびまん性冠動脈病変」に対する自己血管と脂肪組織移植による革新的治療法開発を開始した。まず、豚に食餌性高脂血症を誘導して、バルーン擦過によるびまん性冠動脈病変の作成に着手した。今後、脂肪、血管の移植手術の手技の確立、長期予後などの解析を行なっていく予定である。

Research Products

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• [Journal Article] Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer. (2013)
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• [Journal Article] Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model. (2013)
  • Author(s): Hirata Y, Kurobe H, Uematsu E, Yagi S, Soeki T, Yamada H, Fukuda D, Shimabukuro M, Nakayama M, Matsumoto K, Sakai Y, Kitagawa T, Sata M.
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• [Journal Article] Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. (2013)
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• [Journal Article] Eosinophilic Myocarditis due to Churg-Strauss syndrome with markedly elevated Eosinophil Cationic Protein. (2013)
  • Author(s): Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
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• [Journal Article] Constrictive pericarditis with intrapericardial abscess. (2013)
  • Author(s): Hara T, Yamada H, Takashima A, Yamasaki H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M
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• [Journal Article] Spectacular migration of a central venous catherter into the pulmonary artery. (2013)
  • Author(s): Hara T, Sata M.
  • Journal Title: Heart Asia Volume: 5 Pages: 42-43
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• [Journal Article] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis. (2013)
  • Author(s): Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
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• [Journal Article] Patent foramen ovale diagnosed by real-time three-dimensional contrast transesophageal echocardiography: A case report. (2013)
  • Author(s): Tomita N, Yamada H, Nishio S, Tamai R, Kusunose K, Hayashi S, Hotchi J, Sata M
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• [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury. (2013)
  • Author(s): Yoichiro Hirata
  • Journal Title: European Journal of Pharmacology Volume: 699 Pages: 106-111
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• [Journal Article] Ulcer-like projection caused by a penetrating branch to the bronchial artery. (2013)
  • Author(s): Takayuki Ise
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• [Journal Article] Perivascular adipose tissue-secreted angiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury. (2013)
  • Author(s): Zhe Tian
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• [Journal Article] A novel doppler echocardiographic index integrating left and right ventricular function is superior to conventional indices for predicting adverse outcome of acute myocardial infarction. (2013)
  • Author(s): Yamato Fukuda
  • Journal Title: The Journal of Medical Investigation Volume: 60 Pages: 97-105
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• [Journal Article] Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine. (2013)
  • Author(s): Michio Shimabukuro
  • Journal Title: The Journal of Medical Investigation Volume: 60 Pages: 1-4
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• [Journal Article] Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure. (2013)
  • Author(s): Kenya Kusunose
  • Journal Title: JACC: Cardiovascular Imaging Volume: 6 Pages: 528-530
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• [Journal Article] Miglitol, α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: A randomized comparable study. (2013)
  • Author(s): Michio Shimabukuro
  • Journal Title: International Journal of Cardiology Volume: in press Pages: in press
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• [Journal Article] Renin-angiotensin-aldosterone system plays a pivotal role in cognitive impairment. (2013)
  • Author(s): Shusuke Yagi
  • Journal Title: Hypertension Research Volume: in press Pages: in press
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• [Journal Article] Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model. (2013)
  • Author(s): Munehisa Shimamura
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: in press Pages: in press
  • DOI: 10.1038/jcbfm.2013.62.
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• [Journal Article] Expanded roles of the renin-angiotensin system. (2013)
  • Author(s): Daiju Fukuda
  • Journal Title: Hypertension Research Volume: in press Pages: in press
  • DOI: 10.1038/hr.2013.27
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• [Journal Article] Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice. (2012)
  • Author(s): Higashikuni Y, Takaoka M, Iwata H, Tanaka K, Hirata Y, Nagai Y, Sata M.
  • Journal Title: Hypertens Res. Volume: 35 Pages: 62-69
  • DOI: doi:10.1038/hr.2011.136
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• [Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. (2012)
  • Author(s): Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Kimie T, Sahara M, Hirata Y, Nagai R, Sata M.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 32 Pages: 654-661
  • DOI: doi:10.1161/ATVBAHA.111.240341
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• [Journal Article] Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension. (2012)
  • Author(s): Sahara M, Sata M, Morita T, Hirata Y, Nagai R.
  • Journal Title: PLoS One. Volume: 7 Pages: e33367
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• [Journal Article] Effects of statins on cardiorenal syndrome. (2012)
  • Author(s): Yagi S, Aihara K, Ikeda Y, Akaike M, Sata M, Matsumoto T.
  • Journal Title: Int J Vasc Med. Volume: 162545 Pages: 7
  • DOI: doi:10.1155/2012/162545
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• [Journal Article] A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery. (2012)
  • Author(s): Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.
  • Journal Title: Int Heart J Volume: 53 Pages: 170-175
  • DOI: doi:10.1536/ihj.53.170
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• [Journal Article] Bicuspid aortic valve endocarditis complicated by perivalvular abscess. (2012)
  • Author(s): Hara T, Soeki T, Niki T, Kusunose K, Yamaguchi K, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Sata M.
  • Journal Title: J Med Invest. Volume: 59 Pages: 261-265
  • DOI: doi:10.2152/jmi.59.261
  • Peer Reviewed
• [Journal Article] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects. (2012)
  • Author(s): Dagvasumberel M, Shimabukuro M, Nishiuchi T, Ueno J, Takao S, Fukuda D, Hirata Y, Kurobe H, Soeki T, Iwase T, Kusunose K, Niki T, Yamaguchi K, Taketani Y, Yagi S, Tomita N, Yamada H, Wakatsuki T, Harada M, Kitagawa T, Sata M.
  • Journal Title: Cardiovasc Diabetol. Volume: 11 Pages: 106
  • DOI: doi:10.1186/1475-2840-11-106
  • Peer Reviewed
• [Journal Article] Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects. (2012)
  • Author(s): Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Sakaue H, Nakaya Y, Masuzaki H, Sata M.
  • Journal Title: Eur J Pharmacol Volume: 692 Pages: 84-90
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• [Journal Article] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway. (2012)
  • Author(s): Ikeda Y, Aihara KI, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihara Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T.
  • Journal Title: J Biol Chem. Volume: 287 Pages: 34256-34263
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• [Journal Article] Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate. (2012)
  • Author(s): Kusunose K, Yamada H, Nishio S, Tomita N, Hotchi J, Bando M, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: J Am Soc Echocardiogr. Volume: 25 Pages: 953-959
  • DOI: doi:10.1016/j.echo.2012.06.009
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• [Journal Article] Double-chambered right ventricle presenting significant outflow tract obstruction only in the right decubitus position. (2012)
  • Author(s): Hayashi S, Yamada H, Nishio N, Tomita N, Hotchi J, Bando M, Nakagawa M, Tamai R, Hirota D, Hirata Y, Sata M.
  • Journal Title: J Echocardiogr Volume: 10 Pages: 146-147
  • DOI: doi:10.1007/s12574-012-0145-x
  • Peer Reviewed
• [Journal Article] The role of epicardial adipose tissue in atrial fibrillation. (2012)
  • Author(s): Soeki T, Sata M.
  • Journal Title: Circ J Volume: 76 Pages: 2738-2739
  • DOI: doi:10.1253/circj.CJ-12-1283
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• [Journal Article] A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury. (2012)
  • Author(s): Yoichiro Hirata
  • Journal Title: European Journal of Pharmacology Volume: 674 Pages: 352-358
  • DOI: 10.1016/j.ejphar.2011.10.038
  • Peer Reviewed
• [Journal Article] Intensive glucose lowering in cardiovascular risk management. (2012)
  • Author(s): Michio Shimabukuro
  • Journal Title: Circulation Journal Volume: 76 Pages: 593-595
  • DOI: 10.1253/circj.CJ-12-0062
  • Peer Reviewed
• [Journal Article] Massive splenic infarction due to left ventricular apical thrombus in a patient with giant splenomegaly. (2012)
  • Author(s): Tomoya Hara
  • Journal Title: Heart Asia Volume: 4 Pages: 53-53
  • DOI: 10.1136/heartasia-2011-010070
  • Peer Reviewed
• [Journal Article] Autologous peripheral blood-derived mononuclear cells induced by erythropoietin improve critical ischemic limbs. (2012)
  • Author(s): Tamotsu Kanbara
  • Journal Title: Annals of Vascular Surgery Volume: 5 Pages: 52-60
  • DOI: 10.3400/avd.oa.11.00070
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• [Journal Article] Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. (2012)
  • Author(s): Yasuharu Watanabe
  • Journal Title: Diabetes Volume: 61 Pages: 1199-1209
  • DOI: 10.2337/db11-1182
  • Peer Reviewed
• [Journal Article] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice. (2012)
  • Author(s): Asuka Shiota
  • Journal Title: Cardiovascular Diabetology Volume: 11 Pages: 139-139
  • DOI: 10.1186/1475-2840-11-139
  • Peer Reviewed
• [Journal Article] Renoprotective and antioxidant effects of cilnidipine in hypertensive patients. (2012)
  • Author(s): Takeshi Soeki
  • Journal Title: Hypertension Research Volume: 35 Pages: 1058-1062
  • DOI: 10.1038/hr.2012.96
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients. (2012)
  • Author(s): Ken Yamakawa
  • Journal Title: Cardiology Research and Practice Volume: 2012 Pages: 754181
  • DOI: 10.1155/2012/754181
  • Peer Reviewed
• [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. (2012)
  • Author(s): Takeya Minami
  • Journal Title: The EMBO Journal Volume: 31 Pages: 4428-4440
  • DOI: 10.1038/emboj.2012.296
  • Peer Reviewed
• [Journal Article] A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion.
  • Author(s): Hara T, Wakatsuki T, Taketani Y, Yamaguchi K, Iwase T, Sata M.
  • Journal Title: Cardiovasc Interv Ther. Volume: (in press)
  • DOI: doi:10.1007/s12928-013-0158-z
  • Peer Reviewed
• [Journal Article] Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects.
  • Author(s): Kurobe H, Matsuoka Y, Hirata Y, Sugasawa N, Maxfield MW, Sata M, Kitagawa T
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  • DOI: doi:10.1016/j.jtcvs.2013.02.073
  • Peer Reviewed
• [Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.
  • Author(s): Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, Ise T, Ueda Y, Tomita N, Yamaguchi K, Koshiba K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Shimabukuro M, Kishimoto I, Kangawa K, Sata M.
  • Journal Title: Heart Vessels Volume: (in press)
  • DOI: doi:10.1007/s00380-013-0333-2
  • Peer Reviewed
• [Presentation] Ectopic Fat Depositions and Diabetic Vascular Disease. (2013)
  • Author(s): Michio Shimabukuro
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Cardiospecific microRNA Plasma Levels are Associated With Coronary Plaque Vulnerability. (2013)
  • Author(s): Takeshi Soeki
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Epicardial Adipose Tissue Volume as a Novel Determinant of Human Coronary Atherosclerosis: Role of Adipocytokine Imbalance. (2013)
  • Author(s): Michio Shimabukuro
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Eicosapentaenoic Acid Ameliorates Survival and Ventricular Remodeling after Myocardial Infarction by Reducing Inflammatory Responses in Mice. (2013)
  • Author(s): Yasutomi Higashikuni
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Relationship between NLRP3 Inflammasome Activation in Adipose Tissue and Atherosclerosis. (2013)
  • Author(s): Sachiko Bando
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Toll-Like Receptor 2-Mediated Inflammation is Critically Involved in Cardiac Adaptive Response to Pressure Overload. (2013)
  • Author(s): Yasutomi Higashikuni
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Effect of Eicosapentaenoic Acid on the Stabilization of Vulnerability in Carotid Artery Plaque: Evaluation Using iPlaque® Software. (2013)
  • Author(s): Mika Bando
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Pentraxin 3 is a Local Inflammatory Marker in Atrial Fibrillation. (2013)
  • Author(s): Takeshi Soeki
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Augmentation Index Measured by Tonometry Significantly Underestimates Atrial Stiffness in Ischemic Heart Disease in Japanese Population. (2013)
  • Author(s): Shuji Hayashi
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] MicroRNA-100 Regulates Adipocytokine Expression in Subcutaneous and Visceral Adipose Tissue: An Observation from Human Biopsy Study. (2013)
  • Author(s): Masayoshi Ishida
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Genetic Ablation of TLR9 Improves Insulin Resistance through the Reduction of Hepatic SREBP-1c Expression. (2013)
  • Author(s): Daiju Fukuda
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Effects of Ezetimibe on Oxidized Cholesterol and Fatty-acid Components in Epicardial Fat and Myocardium: A Gas Chromatography-Mass Spectrometry Analysis. (2013)
  • Author(s): Michio Shimabukuro
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Effects of Additional Eicosapentaenoic Acid Therapy on Inflammatory Cytokines and Atherosclerotic Plaque Component Assessed by Integrated Backscatter Ultrasound Systems. (2013)
  • Author(s): Toshiyuki Niki
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Effects of Tolvaptan are Predicted by Vasopressin/Aldosterone Ratio and Urine Osmolality in Patients with Chronic Heart Failure. (2013)
  • Author(s): Muneyuki Kadota
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance. (2013)
  • Author(s): Takashi Iwase
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Differential Responses of Local Coagulation after Implantation of Everolimus-Eluting Stent Compared with Early-Generation Drug-Eluting Stents. (2013)
  • Author(s): Koji Yamaguchi
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Local Administration of Suramin Inhibits Angiogenesis in Adventitia and Arterial Lesion Progression in Apolipoprotein E-deficient Mice. (2013)
  • Author(s): Kimie Tanaka
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Evaluation of Right Ventricular Hypertrophy by Cardiac Magnetic Resonance is Useful for Detecting Cardiac Amyloidosis. (2013)
  • Author(s): Takayuki Ise
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed by Integrated Backscatter Intravascular Ultrasound. (2013)
  • Author(s): Koji Yamaguchi
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Macrophage-specific HIF-1a-deficient Mice Suppress Vascular Remodeling. (2013)
  • Author(s): Taisuke Nakayama
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Adaptive Servo-Ventilation Improves Symptoms and Hemodynamics in Both Patients with Systolic and Diastolic Heart Failure. (2013)
  • Author(s): Takayuki Ise
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] A Renin Inhibitor Prevents Atrial Endocardial Dysfunction in Rapidly Paced Rats with Streptozotocin-induced Diabetes. (2013)
  • Author(s): Tomomi Matsuura
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130317
• [Presentation] Ratio of Eicosapentaenoic Acid to Arachidonic Acid is a Predictive Factor of Albuminuria and Endothelial Function in Patients with Dyslipidemia. (2013)
  • Author(s): Shusuke Yagi
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20130315-20130315
• [Presentation] Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque. (2013)
  • Author(s): Mika Bando
  • Organizer: ACC 2013
  • Place of Presentation: The Moscone Center (America)
  • Year and Date: 20130309-20130311
• [Presentation] A Pleitropic effect of N-type Ca channel blocker Up-close to the drug effect of CCB. (2012)
  • Author(s): Masataka Sata
  • Organizer: The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
  • Place of Presentation: あわぎんﾎｰﾙ （徳島県）
  • Year and Date: 20121205-20121207
  • Invited
• [Presentation] Angiogenesis in atherosclerosis. (2012)
  • Author(s): Kimie Tanaka
  • Organizer: The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
  • Place of Presentation: あわぎんﾎｰﾙ （徳島県）
  • Year and Date: 20121205-20121207
• [Presentation] 慢性炎症と心不全 (2012)
  • Author(s): 佐田政隆
  • Organizer: 第16回日本心不全学会学術集会
  • Place of Presentation: 仙台国際センター (宮城県）
  • Year and Date: 20121130-20121202
  • Invited
• [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Heart Failure. (2012)
  • Author(s): Takayuki Ise
  • Organizer: 第16回日本心不全学会学術集会
  • Place of Presentation: 仙台国際センター (宮城県）
  • Year and Date: 20121130-20121202
• [Presentation] Prediction of Responder and Influence for Cardio-Renal Interaction by Tolvaptan in Patients with Chronic Heart Failure. (2012)
  • Author(s): Muneyuki Kadota
  • Organizer: 第16回日本心不全学会学術集会
  • Place of Presentation: 仙台国際センター (宮城県）
  • Year and Date: 20121130-20121202
• [Presentation] Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients. (2012)
  • Author(s): Koji Yamaguchi
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-20121207
• [Presentation] Relationship Between Nlrp3 Inflammasome and Coronary Atherosclerosis. (2012)
  • Author(s): Sachiko Bando
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-20121107
• [Presentation] Locally Applied Suramin inhibits Angiogenesis in Adventitia and Arterial Lesion Progression in Apolipoprotein E-deficient Mice. (2012)
  • Author(s): Kimie Tanaka
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-20121107
• [Presentation] Cardiac Rehabilitation Reduces Levels of Oxidized LDL. (2012)
  • Author(s): Akira Takashima
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-20121107
• [Presentation] Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems. (2012)
  • Author(s): Toshiyuki Niki
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-20121107
• [Presentation] Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload. (2012)
  • Author(s): Higashikuni Y. Nagai R, Sata M.他2名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Low Left Ventircular Contractile Capacity and Low eGFR Are Significant Predictors for Hyperkalemia in 364 Patients with Heart Failure. (2012)
  • Author(s): Shimabukuro M. 他10名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure. (2012)
  • Author(s): Ise T. 他15 名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] The Innate Immune System, Nlrp3 Inflammasome is Intensified in Epicardial Adipose Tissue around Coronary Arterial Lesions: Evidence from Biopsied Adipose Tissue in Coronary Artery Bypass Surgery. (2012)
  • Author(s): Sato H. 他10名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease. (2012)
  • Author(s): Kimura S. 他18名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Inflammation in atherosclerosis and adipose tissue. (2012)
  • Author(s): Masataka Sata
  • Organizer: The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting 2012
  • Place of Presentation: 学術総合センター （東京都）
  • Year and Date: 20121023-20121026
  • Invited
• [Presentation] 血管機能診断法 (2012)
  • Author(s): 佐田政隆
  • Organizer: 第53回日本脈管学会総会
  • Place of Presentation: 東京ステーションコンファレンス （東京都）
  • Year and Date: 20121011-20121013
  • Invited
• [Presentation] Metabolic Syndrome and Atherosclerosis. (2012)
  • Author(s): Masataka Sata
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ｳｪｽﾃｨﾝﾅｺﾞﾔｷｬｯｽﾙ （愛知県）
  • Year and Date: 20120920-20120922
  • Invited
• [Presentation] 高脂血症から心臓を守る (2012)
  • Author(s): 佐田政隆
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 石川県立音楽堂 （石川県）
  • Year and Date: 20120914-20120916
  • Invited
• [Presentation] 動脈硬化と異所性脂肪 (2012)
  • Author(s): 佐田政隆
  • Organizer: 第3回Molecular Cardiovascular Conference II
  • Place of Presentation: ﾎﾃﾙﾋﾟｱﾉ （北海道）
  • Year and Date: 20120907-20120909
  • Invited
• [Presentation] Locally applied suramin inhibits angiogenesis in adventitia and arterial lesion progression in apolipoprotein E-deficient mice. (2012)
  • Author(s): Kimie Tanaka
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS. (2012)
  • Author(s): Toshiyuki Niki
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] Gender disparities in the association of epicardial adipose tissue volume and coronary atherosclerosis: a 256-slice multidetector computed tomography study. (2012)
  • Author(s): Munkhbaatar Dagvasumberel
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] The innate immune system, NLRP3 inflammasome, in epicardial adipose tissue intensifies human coronary atherosclerosis. (2012)
  • Author(s): Hiromi Sato
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] Region-specific regulation of the innate immune system, NLRP3 inflammasome, in human abdominal adipose tissue. (2012)
  • Author(s): Hiromi Sato
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] Renoprotective effect of cilnidipine via the antioxidant activity in hypertensive patients. (2012)
  • Author(s): Takeshi Soeki
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity. (2012)
  • Author(s): Takeshi Soeki
  • Organizer: ESC Congress 2012
  • Place of Presentation: ﾒｯｾ ﾐｭﾝﾍﾝ （Germany）
  • Year and Date: 20120825-20120829
• [Presentation] Adventitial angiogenesis plays an important role in the pathogenesis of atherosclerosis. (2012)
  • Author(s): Masataka Sata
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ﾎﾃﾙ日航福岡 （福岡県）
  • Year and Date: 20120705-20120706
  • Invited
• [Presentation] Non-invasive Assessment of Left Atrial-Left Ventricular-Arterial Coupling in Patients With Diabetes Mellitus. (2012)
  • Author(s): Susumu Nishio
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
  • Invited
• [Presentation] Assessment of Tricuspid Annular Motion Velocities in Pulmonary Hypertension of Various Etiologies. (2012)
  • Author(s): Junko Hotchi
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
• [Presentation] Efficacy of Six-minute Walk Stress Echocardiography for Detection of Pulmonary Arterial Hypertension in Patients With Connective Tissue Disease. (2012)
  • Author(s): Junko Hotchi
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
• [Presentation] Effect of Statin Therapy on Regression of Carotid Artery Plaque Assessed by High-Resolution Color Mapping Method Based on Integrated Backscatter. (2012)
  • Author(s): Mika Bando
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
• [Presentation] Differentiation Between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease Using Tricuspid Annular Motion Velocity. (2012)
  • Author(s): Shuji Hayashi
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
• [Presentation] Left Ventricular Geometry and Function in Patients with Sigmoid Septum. (2012)
  • Author(s): Mika Bando
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
• [Presentation] Differentiation of Left Atrial Dysfunction From Pseudonormal/Restrictive Transmitral Flow Velocity Pattern in Patients With Preserved Ejection Fraction. (2012)
  • Author(s): Shuji Hayashi
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gayload National (America)
  • Year and Date: 20120630-20120703
• [Presentation] 合成低分子化合物による内因性増殖因子発現誘導と循環器疾患の治療への応用 (2012)
  • Author(s): 佐田政隆
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: ﾊﾟｼﾌｨｺ横浜 （神奈川県）
  • Year and Date: 20120612-20120614
  • Invited
• [Presentation] Epicardial adipose tissue plays a role in the pathogenesis of Atherosclerosis. (2012)
  • Author(s): Masataka Sata
  • Organizer: APSC Subspecialty Congress-Intervention and Imaging 2012
  • Place of Presentation: Taipei International Convention Center (Taiwan)
  • Year and Date: 20120504-20120506
  • Invited
• [Book] Annual Review 循環器2013（編集 小室一成、佐地勉、坂田隆造、赤阪隆史） （5. 動脈硬化とアレルギー・炎症 共著） (2013)
  • Author(s): 田中君枝
  • Total Pages: 288
  • Publisher: 中外医学社
• [Book] エビデンスに基づく循環器病予防医学－慢性心不全を防ぐ予防戦略とは？－（和泉徹 監修） （第II章 8 トランスレーショナルリサーチに期待する予防医学 共著） (2012)
  • Author(s): 田中君枝
  • Total Pages: 417
  • Publisher: 南山堂
• [Book] 循環器疾患 最新の治療2012-2013（堀正二、永井良三 編集） （心臓病と肥満－メタボリックシンドロームを中心に－ 共著） (2012)
  • Author(s): 島袋充生
  • Total Pages: 604
  • Publisher: 南江堂
• [Book] EBM循環器疾患の治療 2012-2013 （小室一成、横井宏佳、山下武志、楽木宏実 編集） （6. 不安定プラーク破裂に関与する因子は何か？ 共著） (2012)
  • Author(s): 山口浩司
  • Total Pages: 424
  • Publisher: 中外医学社
• [Book] 増刊 レジデントノート 循環器診療の疑問、これで納得！(村上裕二 編集) （第2章 7. むずかしくてイヤになる動脈硬化のサイエンス 共著） (2012)
  • Author(s): 添木武
  • Total Pages: 244
  • Publisher: 羊土社
• [Book] 今日の循環器疾患治療指針 第3版（編集 井上博、許俊鋭、檜垣實男、代田浩之、筒井裕之） （4. 治療薬総論 硝酸薬 共著） (2012)
  • Author(s): 竹谷善雄
  • Total Pages: 938
  • Publisher: 医学書院
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部循環器内科学
  • URL: http://square.umin.ac.jp/~TOKUSHIM/