Development of a novel revascularization method to treat diffuse coronary artery diseases with transplantation of artery and adipose tissues

2012 Fiscal Year Final Research Report

• Project/Area Number: 24659392
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SATA Masataka 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (80345214)
• Project Period (FY): 2012
• Keywords: 動脈硬化 / 分子血管病態学 / バイパス手術 / 脂肪組織 / アディポサイトカイン

Research Abstract

To elucidate the pathophysiology of human diffuse coronary atherosclerotic lesions, we analyzed the endarterectomy samples obtained during cardiac bypass surgery. We found enhanced infiltration of inflammatorycells such as macrophages and T cells not only in vessel wall but also in perivascular adipose tissues. These chronic inflammation was associated with augmented angiogenesis. Based on this observation, we started to develop a novel revascularization method to treat diffuse coronary artery diseases with transplantation of own artery and adipose tissues.

Research Products

• [Journal Article] Defects of vascular nitric oxide bioavailability in subjects with impaired glucose tolerance: A potential link to insulin resistance. (2013)
  • Author(s): Shimabukuro M, Higa N, Tagawa T, Yamakawa K, Sata M, Ueda S
  • Journal Title: Int J Cardiol Volume: 167 Pages: 298-300
  • DOI: doi:10.1016/j.ijcard.2012.09.194
  • Peer Reviewed
• [Journal Article] Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer. (2013)
  • Author(s): Kawano N, Yamaguchi K, Niki T, Yamamoto T, Iwase T, Taketani T, Ise T, Yamada H, Soeki T, Wakatsuki T, Kawano K, Kakutani K, Sata M.
  • Journal Title: JC Cases. Volume: 7 Pages: e176-e180
  • DOI: doi:10.1016/j.jccase.2013.02.009
  • Peer Reviewed
• [Journal Article] Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model. (2013)
  • Author(s): Hirata Y, Kurobe H, Uematsu E, Yagi S, Soeki T, Yamada H, Fukuda D, Shimabukuro M, Nakayama M, Matsumoto K, Sakai Y, Kitagawa T, Sata M.
  • Journal Title: Eur J Pharmacol. Volume: 699 Pages: 81-87
  • DOI: doi:10.1016/j.ejphar.2012.11.045
  • Peer Reviewed
• [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury (2013)
  • Author(s): Hirata Y, Kurobe H, Nishio C, Tanaka K, Fukuda D, Uematsu E, Nishimoto S, Soeki T, Harada N, Sakaue H, Kitagawa T, Shimabukuro M, Nakaya N, Sata M.
  • Journal Title: Eur J Pharmacol Volume: 699 Pages: 106-111
  • DOI: doi:10.1016/j.ejphar.2012.11.057
  • Peer Reviewed
• [Journal Article] Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. (2013)
  • Author(s): Yamauchi H, Motomura N, Chung UI, Sata M, Takai D, Saito A, Ono M, Takamoto S
  • Journal Title: J Thorac Cardiovasc Surg Volume: 145 Pages: 522-530
  • DOI: doi:10.1016/j.jtcvs.2012.03.010
  • Peer Reviewed
• [Journal Article] Eosinophilic Myocarditis due to Churg-Strauss syndrome with markedly elevated Eosinophil Cationic Protein. (2013)
  • Author(s): Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: Int Heart J Volume: 5451-53 Pages: 51-53
  • DOI: doi:10.1536/ihj.54.51
  • Peer Reviewed
• [Journal Article] Ulcer-like projection caused by a penetrating branch to the bronchial artery (2013)
  • Author(s): Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M.
  • Journal Title: J Am Coll Cardiol. Volume: 61 Pages: e147
  • DOI: doi:10.1016/j.jacc.2012.10.047
  • Peer Reviewed
• [Journal Article] Constrictive pericarditis with intrapericardial abscess. (2013)
  • Author(s): Hara T, Yamada H, Takashima A, Yamasaki H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M
  • Journal Title: Circ J. Volume: 77 Pages: 786-788
  • DOI: doi:10.1253/circj.CJ-12-1098
  • Peer Reviewed
• [Journal Article] Perivascular adipose tissue-secretedangiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury. (2013)
  • Author(s): Tian Z, Miyata K, Tazume H, Sakauguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M, Oike Y.
  • Journal Title: J Mol Cell Cardiol. Volume: 57 Pages: 1-12
  • DOI: doi:10.1016/j.yjmcc.2013.01.004
  • Peer Reviewed
• [Journal Article] Spectacular migration of a central venous catherter into the pulmonary artery. (2013)
  • Author(s): Hara T, Sata M.
  • Journal Title: Heart Asia Volume: 5 Pages: 42-43
  • DOI: doi:10.1136/heartasia-2013-010287
  • Peer Reviewed
• [Journal Article] A novel doppler echocardiographic index integrating left and right ventricular function is superior to conventional indices for predicting adverse outcome of acute myocardial infarction (2013)
  • Author(s): Fukuda Y, Soeki T, Sata M.
  • Journal Title: J Med Invest Volume: 60 Pages: 97-105
  • Peer Reviewed
• [Journal Article] Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine (2013)
  • Author(s): Shimabukuro M, Kozuka C, Taira T, Yabiku K, Dagvasumberel M, Ishida M, Matsumoto S, Yagi Y, FukudaD, Yamakawa K, Higa M, Soeki T, Yoshida H, Masuzaki H, Sata M
  • Journal Title: J Med Invest Volume: 60 Pages: 1-14
  • DOI: doi:10.2152/jmi.60.1
  • Peer Reviewed
• [Journal Article] Interval from the Onset of Transmitral Flow to Annular Velocity Is a Marker of LV Filling Pressure (2013)
  • Author(s): Kusunose K, Yamada H, Nishio S, Tomita N, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: JACC Cardiovasc Imaging Volume: 6 Pages: 528-530
  • DOI: doi:10.1016/j.jcmg.2012.10.025
  • Peer Reviewed
• [Journal Article] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis. (2013)
  • Author(s): Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 33 Pages: 1077-1084
  • DOI: doi:10.1161/ATVBAHA.112.300829
  • Peer Reviewed
• [Journal Article] Patent foramen ovale diagnosed by real-time three-dimensional contrast transesophageal echocardiography: A case report. (2013)
  • Author(s): Tomita N, Yamada H, Nishio S, Tamai R, Kusunose K, Hayashi S, Hotchi J, Sata M
  • Journal Title: JC Cases Volume: 7 Pages: e91-e92
  • DOI: doi:10.1016/j.jccase.2012.10.011
  • Peer Reviewed
• [Journal Article] Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice. (2012)
  • Author(s): Higashikuni Y, Takaoka M, Iwata H, Tanaka K, Hirata Y, Nagai Y, Sata M.
  • Journal Title: Hypertens Res. Volume: 35 Pages: 62-69
  • DOI: doi:10.1038/hr.2011.136
  • Peer Reviewed
• [Journal Article] A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury (2012)
  • Author(s): Hirata Y, Shimabukuro M, Uematsu E, Soeki T, Yamada H, Sakai Y, Nakamura M, Matsumoto K, Igarashi T, Sata M.
  • Journal Title: Eur J Pharmacol. Volume: 674 Pages: 352-358
  • DOI: doi:10.1016/j.ejphar.2011.10.038
  • Peer Reviewed
• [Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. (2012)
  • Author(s): Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Kimie T, Sahara M, Hirata Y, Nagai R, Sata M.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 32 Pages: 654-661
  • DOI: doi:10.1161/ATVBAHA.111.240341
  • Peer Reviewed
• [Journal Article] Intensive Glucose Lowering in Cardiovascular Risk Management. (2012)
  • Author(s): Shimabukuro M, Masuzaki H, Sata M
  • Journal Title: Circ J Volume: 76 Pages: 593-595
  • DOI: doi:10.1253/circj.CJ-12-0062
  • Peer Reviewed
• [Journal Article] Massive splenic infarction due to left ventricular apical thrombus in a patient with giant splenomegaly (2012)
  • Author(s): Hara T, Yamaguchi K, Sata M.
  • Journal Title: Heart Asia Volume: 4 Pages: 53
  • DOI: doi:10.1136/heartasia-2011-010070
  • Peer Reviewed
• [Journal Article] Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension. (2012)
  • Author(s): Sahara M, Sata M, Morita T, Hirata Y, Nagai R.
  • Journal Title: PLoS One. Volume: 7 Pages: e33367
  • DOI: doi:10.1371/journal.pone.0033367
  • Peer Reviewed
• [Journal Article] Autologous peripheral blood-derived mononuclear cells induced by erythropoietin improve critical ischemic limbs (2012)
  • Author(s): Kanbara T, Kurobe H, Kitaichi T, Sugano M, Nakayama T, Kinoshita H, Iwase T, Akaike M, Abe M, Sata M, Matsumoto T, Kitagawa T.
  • Journal Title: Ann Vasc Dis. Volume: 5 Pages: 52-60
  • DOI: doi:10.3400/avd.oa.11.00070
  • Peer Reviewed
• [Journal Article] The Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation (2012)
  • Author(s): Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama H, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y.
  • Journal Title: Diabetes Volume: 61 Pages: 1199-1209
  • DOI: doi:10.2337/db11-1182
  • Peer Reviewed
• [Journal Article] Effects of statins on cardiorenal syndrome. (2012)
  • Author(s): Yagi S, Aihara K, Ikeda Y, Akaike M, Sata M, Matsumoto T.
  • Journal Title: Int J Vasc Med. Volume: 162545 Pages: 7
  • DOI: doi:10.1155/2012/162545
  • Peer Reviewed
• [Journal Article] A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery. (2012)
  • Author(s): Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Yamashina A.
  • Journal Title: Int Heart J Volume: 53 Pages: 170-175
  • DOI: doi:10.1536/ihj.53.170
  • Peer Reviewed
• [Journal Article] Bicuspid aortic valve endocarditis complicated by perivalvular abscess. (2012)
  • Author(s): Hara T, Soeki T, Niki T, Kusunose K, Yamaguchi K, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Sata M.
  • Journal Title: J Med Invest. Volume: 59 Pages: 261-265
  • DOI: doi:10.2152/jmi.59.261
  • Peer Reviewed
• [Journal Article] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects. (2012)
  • Author(s): Dagvasumberel M, Shimabukuro M, Nishiuchi T, Ueno J, Takao S, Fukuda D, Hirata Y, Kurobe H, Soeki T, Iwase T, Kusunose K, Niki T, Yamaguchi K, Taketani Y, Yagi S, Tomita N, Yamada H, Wakatsuki T, Harada M, Kitagawa T, Sata M.
  • Journal Title: Cardiovasc Diabetol. Volume: 11 Pages: 106
  • DOI: doi:10.1186/1475-2840-11-106
  • Peer Reviewed
• [Journal Article] Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects. (2012)
  • Author(s): Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Sakaue H, Nakaya Y, Masuzaki H, Sata M.
  • Journal Title: Eur J Pharmacol Volume: 692 Pages: 84-90
  • DOI: doi:10.1016/j.ejphar.2012.07.026
  • Peer Reviewed
• [Journal Article] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway. (2012)
  • Author(s): Ikeda Y, Aihara KI, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihara Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T.
  • Journal Title: J Biol Chem. Volume: 287 Pages: 34256-34263
  • DOI: doi:10.1074/jbc.M112.353532
  • Peer Reviewed
• [Journal Article] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice (2012)
  • Author(s): Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Maeda N, Sakaue H, Masuzaki H, Shimomura I, Sata M.
  • Journal Title: Cardiovascular Diabetol. Volume: 11 Pages: 139
  • DOI: doi:10.1186/1475-2840-11-139
  • Peer Reviewed
• [Journal Article] Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate. (2012)
  • Author(s): Kusunose K, Yamada H, Nishio S, Tomita N, Hotchi J, Bando M, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M.
  • Journal Title: J Am Soc Echocardiogr. Volume: 25 Pages: 953-959
  • DOI: doi:10.1016/j.echo.2012.06.009
  • Peer Reviewed
• [Journal Article] Renoprotective and antioxidant effects of cilnidipine in hypertensive patients (2012)
  • Author(s): Soeki T, Kitani M, Kusunose K, Yagi S, Taketani Y, Koshiba K, Wakatsuki T, Orino S, Kawano K, Sata M.
  • Journal Title: Hypertens Res Volume: 35 Pages: 1058-1062
  • DOI: doi:10.1038/hr.2012.96
  • Peer Reviewed
• [Journal Article] Double-chambered right ventricle presenting significant outflow tract obstruction only in the right decubitus position. (2012)
  • Author(s): Hayashi S, Yamada H, Nishio N, Tomita N, Hotchi J, Bando M, Nakagawa M, Tamai R, Hirota D, Hirata Y, Sata M.
  • Journal Title: J Echocardiogr Volume: 10 Pages: 146-147
  • DOI: doi:10.1007/s12574-012-0145-x
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients (2012)
  • Author(s): Yamakawa K, Shimabukuro M, Higa N, Asahi T, Ohba K, Arasaki O, Higa M, Oshiro Y, Yoshida H, Higa T, Saito T, Ueda S, Masuzaki H, Sata M
  • Journal Title: Cardiol Res Pract Volume: 754181 Pages: 9
  • DOI: doi:10.1155/2012/754181
  • Peer Reviewed
• [Journal Article] The role of epicardial adipose tissue in atrial fibrillation. (2012)
  • Author(s): Soeki T, Sata M.
  • Journal Title: Circ J Volume: 76 Pages: 2738-2739
  • DOI: doi:10.1253/circj.CJ-12-1283
  • Peer Reviewed
• [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. (2012)
  • Author(s): Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K.
  • Journal Title: EMBO J. Volume: 31 Pages: 4428-4440
  • DOI: doi:10.1038/emboj.2012.296.
  • Peer Reviewed
• [Journal Article] A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion.
  • Author(s): Hara T, Wakatsuki T, Taketani Y, Yamaguchi K, Iwase T, Sata M.
  • Journal Title: Cardiovasc Interv Ther. Volume: (in press)
  • DOI: doi:10.1007/s12928-013-0158-z
  • Peer Reviewed
• [Journal Article] Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects.
  • Author(s): Kurobe H, Matsuoka Y, Hirata Y, Sugasawa N, Maxfield MW, Sata M, Kitagawa T
  • Journal Title: J Thorac Cardiovasc Surg. Volume: (in press)
  • DOI: doi:10.1016/j.jtcvs.2013.02.073
  • Peer Reviewed
• [Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.
  • Author(s): Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, Ise T, Ueda Y, Tomita N, Yamaguchi K, Koshiba K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Shimabukuro M, Kishimoto I, Kangawa K, Sata M.
  • Journal Title: Heart Vessels Volume: (in press)
  • DOI: doi:10.1007/s00380-013-0333-2
  • Peer Reviewed
• [Journal Article] Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model.
  • Author(s): Shimamura M, Nakagami H, Sata M, Takaoka M, Azuma J, Kiomy Osako M, Koriyama H, Kurinami H, Wakayama K, Miyake T, Morishita R.
  • Journal Title: J Cereb Blood Flow Metab Volume: (in press)
  • DOI: doi:10.1038/jcbfm.2013.62
  • Peer Reviewed
• [Journal Article] Expanded roles of the renin-angiotensin system
  • Author(s): Fukuda D, Sata M.
  • Journal Title: Hypertens Res Volume: (in press)
  • DOI: doi:10.1038/hr.2013.27
  • Peer Reviewed
• [Journal Article] α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: A randomized comparable study.
  • Author(s): Shimabukuro M, Higa M, Yamakawa K, Masuzaki H, Sata M. Miglitol
  • Journal Title: Int J Cardiol Volume: (in press)
  • DOI: doi:10.1016/j.ijcard.2012.05.109
  • Peer Reviewed
• [Presentation] Cardiospecific microRNA Plasma Levels are Associated With Coronary Plaque Vulnerability. (2013)
  • Author(s): Soeki T. 他20名
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20130315-17
• [Presentation] Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque (2013)
  • Author(s): Bando M. 他9 名
  • Organizer: ACC 2013
  • Place of Presentation: The Moscone Center (America)
  • Year and Date: 20130309-11
• [Presentation] Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients (2012)
  • Author(s): Yamaguchi K. 他13 名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload. (2012)
  • Author(s): Higashikuni Y. Nagai R, Sata M.他2名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Low Left Ventircular Contractile Capacity and Low eGFR Are Significant Predictors for Hyperkalemia in 364 Patients with Heart Failure. (2012)
  • Author(s): Shimabukuro M. 他10名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure. (2012)
  • Author(s): Ise T. 他15 名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] The Innate Immune System, Nlrp3 Inflammasome is Intensified in Epicardial Adipose Tissue around Coronary Arterial Lesions: Evidence from Biopsied Adipose Tissue in Coronary Artery Bypass Surgery. (2012)
  • Author(s): Sato H. 他10名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Cardiac Rehabilitation Reduces Levels of Oxidized LDL (2012)
  • Author(s): Takashima A. 他16名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Relationship Between Nlrp3 Inflammasome and Coronary Atherosclerosis (2012)
  • Author(s): Bando S. 他22名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Effect of Cardiac Rehabilitation with Supervised Exercise Training on Urinary Albumin Excretion in Patients with Cardiovascular Disease. (2012)
  • Author(s): Kimura S. 他18名
  • Organizer: AHA Scientific Sessions 2012
  • Place of Presentation: Los Angeles Convention Center (America)
  • Year and Date: 20121103-07
• [Presentation] Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity. (2012)
  • Author(s): Soeki T. 他9名
  • Organizer: ESC Congress 2012
  • Place of Presentation: メッセ ミュンへン(ドイツ)
  • Year and Date: 20120825-29
• [Presentation] Renoprotective effect of cilnidipine via the antioxidant activity in hypertensive patients. (2012)
  • Author(s): Soeki T. 他9名
  • Organizer: ESC Congress 2012
  • Place of Presentation: メッセ ミュンへン(ドイツ)
  • Year and Date: 20120825-29
• [Presentation] Region-specific regulation of the innate immune system, NLRP3 inflammasome, in human abdominal adipose tissue. (2012)
  • Author(s): Sato H. 他9名
  • Organizer: ESC Congress 2012
  • Place of Presentation: メッセ ミュンへン(ドイツ)
  • Year and Date: 20120825-29
• [Presentation] The innate immune system, NLRP3 inflammasome, in epicardial adipose tissue intensifies human coronary atherosclerosis. (2012)
  • Author(s): Sato H. 他9名
  • Organizer: ESC Congress 2012
  • Place of Presentation: メッセ ミュンへン(ドイツ)
  • Year and Date: 20120825-29
• [Presentation] Gender disparities in the association of epicardial adipose tissue volume and coronary atherosclerosis: a 256-slice multidetector computedtomography study (2012)
  • Author(s): Dagvasumberel M. 他8 名
  • Organizer: ESC Congress 2012
  • Place of Presentation: メッセ ミュンへン(ドイツ)
  • Year and Date: 20120825-29
• [Presentation] The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS (2012)
  • Author(s): Niki T. 他9名
  • Organizer: ESC Congress 2012
  • Place of Presentation: メッセ ミュンへン(ドイツ)
  • Year and Date: 20120825-29
• [Presentation] Non-invasive Assessment of Left Atrial-Left Ventricular-Arterial Coupling in Patients With Diabetes Mellitus. (2012)
  • Author(s): Nishio S. 他12名
  • Organizer: American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
  • Place of Presentation: Gaylord National (America)
  • Year and Date: 20120630-0703
• [Book] 『4. 治療薬総論硝酸薬』今日の循環器疾患治療指針 第3 版 (2013)
  • Author(s): 竹谷善雄、佐田政隆
  • Total Pages: 162-165
  • Publisher: 医学書院
• [Book] 『5. 動脈硬化とアレルギー・炎症』 Annual Review 循環器 2013 (2013)
  • Author(s): 田中君枝、佐田政隆
  • Total Pages: 34-40
  • Publisher: 中外医学社
• [Book] 『第II 章 8 トランスレーショナルリサーチに期待する予防医学』 エビデンスに基づく循環器病予防医学-慢性心不全を防ぐ予防戦略とは?- (2012)
  • Author(s): 田中君枝、佐田政隆
  • Total Pages: 96-101
  • Publisher: 南山堂
• [Book] 心臓病と肥満-メタボリックシンドロームを中心に-』 循環器疾患 最新の治療 2011-2012 (2012)
  • Author(s): 島袋充生、佐田政隆
  • Total Pages: 507-510
  • Publisher: 南江堂
• [Book] 『6. 不安定プラーク破裂に関与する因子は何か?』 EBM循環器疾患の治療 2012-2013 (2012)
  • Author(s): 山口浩司、佐田政隆
  • Total Pages: 26-29
  • Publisher: 中外医学社
• [Book] 『2.PPARγ』 動脈硬化症の新しい診断・治療標的 (2012)
  • Author(s): 田中君枝、佐田政隆
  • Total Pages: 75-82
  • Publisher: メディカルレビュー社
• [Book] 『第2 章 7. むずかしくてイヤになる動脈硬化のサイエンス』増刊 レジデントノート 循環器診療の疑問、これで納得! (2012)
  • Author(s): 添木武、佐田政隆
  • Total Pages: 146-152
  • Publisher: 羊土社
• [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部循環器内科学
  • URL: http://square.umin.ac.jp/~TOKUSHIM/