2014 Fiscal Year Final Research Report
Development of the monitoring system for the liver function in hepatectomy
Project/Area Number |
24659604
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Nagoya University |
Principal Investigator |
NAGINO Masato 名古屋大学, 医学(系)研究科(研究院), 教授 (20237564)
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Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Yukihiro 名古屋大学, 医学部附属病院, 講師 (80378091)
KOKURYO Toshio 名古屋大学, 医学系研究科, 特任講師 (60378023)
IGAMI Tuyoshi 名古屋大学, 医学部附属病院, 病院講師 (50420378)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 肝虚血・再灌流 / 一酸化窒素 / 肝障害 |
Outline of Final Research Achievements |
We developed the NO sensor as a real-time monitoring system for the liver function. Intrahepatic NO levels increased and then reached a plateau approximately 15 min after starting ischemia during I/R (ischemia/reperfusion). The sinusoids after 5 min reperfusion were dilated compared with the sinusoids before ischemia during I/R. The phospho-eNOS expression increased during the first ischemia, and then the levels decreased during the subsequent repeating I/R; however, the iNOS expression gradually increased. This study revealed an altered activation of the phospho-eNOS and iNOS over the course of repeated I/R.
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Free Research Field |
消化器外科学
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