Biomolecular mechanism of urinary stone formation, and development of medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659716
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: KENJIRO Kohri 名古屋市立大学, その他部局等, 学長 (30122047)
• Co-Investigator(Kenkyū-buntansha): TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733) ; YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966) ; HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 助教 (80551267)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 尿路結石 / オステオポンチン / ミトコンドリア / マクロファージ

Outline of Final Research Achievements

(1) Thrombin-cleaved osteopontin plays an important role in formation of renal calcium crystals and that 35B6-Ab contributes to the remarkable inhibition of early-stage renal crystal formation by preventing renal tubular cell injury and crystal-cell attachment. (2) To experimentally evaluate the clinical application of N-methyl-4-isoleucine cyclosporin, a novel selective inhibitor of cyclophilin D activation.We first report a new treatment agent determining renal calcium crystallization through cyclophilin D activation. (3)M2Mφ transfusion directly suppressed crystal formation and the marked crystal phagocytic ability of M2Mφs.

Free Research Field

泌尿器科学