Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin

2012 Fiscal Year Final Research Report

• Project/Area Number: 24659730
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: FUJIWARA Hiroshi 京都大学, 医学研究科, 准教授 (30252456)
• Co-Investigator(Kenkyū-buntansha): SATO Yukiyasu 京都大学, 医学研究科, 講師 (00508236) ; HORIE Akihito 京都大学, 医学研究科, 助教 (30535836) ; HATTORI Akira 京都大学, 薬学研究科, 准教授 (50300893) ; ARAKI Yosihiko 順天堂大学, 医学研究科, 准教授 (70250933)
• Project Period (FY): 2012
• Keywords: ヒト絨毛外栄養膜細胞 / laeverin / 免疫寛容 / 胚シグナル

Research Abstract

During human placentation, extravillous trophoblast invades maternal endometrium and remodels spiral arteries. In this study, we examined the physiological roles of a novel human trophoblast-specific soluble factor, laeverin that we identified. We found that soluble-form laeverin induced differentiation of monocytes into dendritic cells and showed possible involvement of laeverin in induction of immune-tolerance in cooperation with HLA-G. These findings provide a new insight into the mechanisms for intrauterine human fetal development.

Research Products

• [Journal Article] Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion (2013)
  • Author(s): Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y and Konishi I
  • Journal Title: Int J Gynecol Cancer. Volume: 23 Pages: 576-82
  • Peer Reviewed
• [Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell. (2013)
  • Author(s): Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H and Araki Y
  • Journal Title: Cancer Biomark Volume: 13 Pages: 141-8
  • Peer Reviewed
• [Journal Article] Mechanism of maternal vascular remodeling during human pregnancy (2012)
  • Author(s): Sato Y, Fujiwara H and Konishi I
  • Journal Title: Reprod Med Biol. Volume: 11 Pages: 27-36
  • Peer Reviewed
• [Journal Article] Laeverin/sminipeptidase Q induces trophoblast invasion during human early placentation. (2012)
  • Author(s): Horie A, Fujiwara H, Sato Y, Sugimami K, Matsumoto H, Maruyama M, Konishi I and Hattori A
  • Journal Title: Human Reprod Volume: 27 Pages: 1267-76
  • DOI: DOI:10.1093/humrep/des068
  • Peer Reviewed
• [Presentation] 月経時の子宮内膜修復過程において、血小板は子宮内膜上皮のintegrityを増強させる (2012)
  • Author(s): 杉並 興、佐藤幸保、堀江昭史、松本久宣、谷 洋彦、藤原 浩、小西郁生
  • Organizer: 第57回日本生殖医学会学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 20121108-09
• [Presentation] Sphingosine-1-phosphate はヒトextravillous trophoblastの浸潤調整に寄与している (2012)
  • Author(s): 松本久宣、佐藤幸保、谷 洋彦、杉並興、堀江昭史、藤原 浩、小西郁生
  • Organizer: 第57回日本生殖医学会学術講演会
  • Place of Presentation: 長崎
  • Year and Date: 20121108-09
• [Presentation] Regulatory role of sphingosine-1-phosphate in migration of human trophoblast (2012)
  • Author(s): Matsumoto H, Sato Y, Suginami K, Horie A, Fujiwara H and Konishi I.
  • Organizer: The 18thInternational Faderation pf Placenta Assosiations Meetiong
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 20120918-21
• [Presentation] 着床における胚・母体間の相互応答と母体組織の再構築
  • Author(s): 藤原 浩
  • Organizer: 第4回産婦人科内分泌研究会