Effect of Botox on the hypertrophied bladder wall in fetal lambs

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659774
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: NAGAE Hideki 聖マリアンナ医科大学, 医学部, 助教 (90468942)
• Co-Investigator(Renkei-kenkyūsha): KITAGAWA Hiroaki 聖マリアンナ医科大学, 医学部, 教授 (80153097) ; WAKISAKA Munechika 聖マリアンナ医科大学, 医学部, 准教授 (30267596)
• Research Collaborator: SEKI Yasuji 聖マリアンナ医科大学, 医学部, 講師 (20309462)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: Botulin Toxin / Fetal surgery

Research Abstract

Posterior Urethral Valves (PUV) is a congenital anomaly almost entirely confined to boys. PUV often develop a specific bladder dysfunction that has become known as [PUV Bladder]. A recent development has been the use of Botulin Toxin (Botox) to treat bladder dysfunction, although this has not yet been tried in [Valve Bladder] patients. This study addresses the questions [will Botox modify the development of the hypertrophied fetal bladder?] and [what is the optimal dose of Botox in International Units/kg in the fetus?] We have shown that the placement of a non-valved shunt produces a hypertrophied bladder. This study is a pilot study to determine the feasibility of using Botox injected into the bladder wall to investigate whether the injection of Botox will improve the bladder development after the placement of a non-valved shunt and attempt to determine a possibly-effective dose.

Research Products

• [Journal Article] 実験的胎児治療 : 新たな膀胱羊水腔シャントチューブの開発 (2013)
  • Author(s): 北川博昭、長江秀樹、眞鍋周太郎、大山慧、關保二、小池淳樹、島秀樹、脇坂宗親、Kevin C.Pringle
  • Journal Title: 小児外科 Volume: 45巻 Pages: 105-112
• [Journal Article] Valved shunt as a treatment for obstructive uropathy : does pressure make a difference? (2013)
  • Author(s): Hiroaki Kitagawa, Yasuji Seki, Hideki Nagae, Takeshi Aoba , Shutaro Manabe, Kei Ooyama , Junki Koike , Masayuki Takagi , Jane Zuccollo , Shinobu Tatsunami , Kevin C. Pringle
  • Journal Title: Pediatr Surg Int Volume: 29 Pages: 381-386
  • Peer Reviewed
• [Presentation] 羊を用いた胎児尿路閉塞モデルの萎縮膀胱に胎児期ボツリヌス注射を用いた効果 (2014)
  • Author(s): 長江秀樹、北川博昭ら
  • Organizer: 日本小児外科学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-05-09