2015 Fiscal Year Final Research Report
Elucidation of molecular and neural-circuit mechanisms of stress susceptibility related to mental illnesses
| Project/Area Number |
24689015
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kobe University (2014-2015)
Kyoto University (2012-2013) |
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Principal Investigator |
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| Research Collaborator |
NARUMIYA Shuh
KITAOKA Shiho
SHINOHARA Ryota
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 脳科学 / 薬理学 / うつ病 / ストレス / 前頭前皮質 / ドパミン / ミクログリア / 自然免疫分子 |
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| Outline of Final Research Achievements |
Stress due to social and environmental stimuli promotes mental illnesses including depression. However, since the mechanism of stress remains elusive, a pharmaceutical strategy targeting stress has not been established. In this study, using repeated social defeat stress, a mouse model of depression, we showed that short-term stress activates dopamine receptors in excitatory neurons in the medial prefrontal cortex and promotes stress resilience, whereas long-term stress activates microglia through innate immune molecules and induces depression-like behaviors. Therefore, this study proposes novel strategies to promote stress resilience for the therapeutic treatment of mental illnesses.
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| Free Research Field |
神経科学、薬理学
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