PET imaging probes for detection and evaluation of atherosclerotic plaques

2015 Fiscal Year Final Research Report

• Project/Area Number: 24689049
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University (2015); Hamamatsu University School of Medicine (2012-2014)
• Principal Investigator: OGAWA Mikako 北海道大学, 薬学研究科(研究院), 教授 (20344351)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: PET / 動脈硬化 / 不安定プラーク

Outline of Final Research Achievements

Disruption of atherosclerotic plaques and the following thrombus formation is currently recognized as the primary mechanism of myocardial and cerebral infarctions. In this study, we compared PET imaging agents, [18F]FDG, [18F]FMISO, [18F]NaF, [11C]Choline, [11C]PK11195, using WHHL rabbit in same animals.
[18F]FDG accumulated into atherogenic M1 macrophges, but SN ratio was not very high. [18F]NaF showed the highest SN ratio, and small region was clearly visualized. Macrophage accumulation was seen with [11C]Choline, however, the signal from the heart and liver disturbed the detection with PET. [11C]PK11195 distribution was different from [18F]FDG, and in some animals, the plaque was not detected due to the high heart uptake. [18F]FMISO did not show significant signal around the atherosclerotic regions.

Free Research Field

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