Towards an integrated understandings of the inflammatory tissue remodeling in the pathogenesis of rheumatoid arthritis

2016 Fiscal Year Final Research Report

• Project/Area Number: 24689056
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya City University (2016); Kyoto University (2012-2015)
• Principal Investigator: ASAGIRI Masataka 名古屋市立大学, 薬学研究科(研究院), 准教授 (20372435)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 関節リウマチ / 自己免疫 / 病理学 / 免疫学 / 炎症 / 組織破壊 / 組織再構築 / 骨代謝

Outline of Final Research Achievements

Inflammatory bone destruction exceeds bone formation in the pathogenesis of rheumatoid arthritis (RA). In this study, we gained insights into the mechanism of RA bone destruction by elucidating a link in various organs in inflammation pathology. As a result, we clarified novel activation mechanisms of NFkB molecules (Nature Immunol 2012; Cell Reports 2012; Blood 2016); identified a subset of cells involved in inflammatory fibrosis (PNAS 2014); and elucidated the role of ion permeable channels and actin binding proteins in bone metabolism (Science Signaling 2016; Scientific Reports 2017).

Free Research Field

病態解析学、免疫学