2013 Fiscal Year Final Research Report
The cell fate regulation mechanism during the development of neocortex controlled by the Hedgehog signaling.
| Project/Area Number |
24700353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 大脳皮質 / 神経発生 / 細胞周期 / ヘッジホッグシグナル / ドパミンニューロン |
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| Research Abstract |
The neocortex comprises several neuronal subtypes and neural glial cells. Differentiation of these cells is regulated by various factors during corticogenesis. In this study, to confirm the mechanism of corticogenesis controlled by the morphogen Hedgehog (HH) signaling, we established conditional knockout (cKO) mice in which the expression of Smo, an HH-signaling mediator, was inhibited in the dorsal telencephalon during development. HH signaling coordinates neurogenesis and cell cycle kinetics via its regulation of cyclin D2 expression. In Smo cKO mice, layer 6b exhibited hypoplasticity with decreased dopaminergic neuronal projections in the prefrontal cortex. These findings suggest that the histologic anomalies in the developing neocortex induced neuronal network abnormalities.
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Research Products
(15 results)
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[Journal Article] WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration2013
Author(s)
Xie M, Yagi H, Kuroda K, Wang C, Komada M, Zhao H, Sakakibara A, Miyata T, Nagata K, Oka Y, Iguchi T, Sato M.
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Journal Title
Cerebral Cortex
Volume: 23
Pages: 1410-1423
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