2013 Fiscal Year Final Research Report
Development of biomarker of Breast cancer and retrospective analysis to confirm clinical efficacy of the biomarker
| Project/Area Number |
24701000
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKAHASHI Shin 東北大学, 加齢医学研究所, 助教 (20431570)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | バイオマーカー / TP53 / 遺伝子発現プロファイル |
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| Research Abstract |
TP53 is tumor suppressor gene and is known as independent prognostic factor in breast cancer. The aim of this study is to develop the biomarker to distinguish TP53 status and to confirm the efficacy of the biomarker. Eighty eight operated breast cancer samples were used. We developed the method to predict TP53 status using gene expression profile. Then we presented that the biomarker could predict the efficacy of chemotherapy by 508 breast cancer cohort data in public database. We expect that the biomarker will improve the prognosis of breast cancer.
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