Radiobiological effect induced by laser-plasma soft x-ray microbeam

2013 Fiscal Year Final Research Report

• Project/Area Number: 24710096
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Quantum beam science
• Research Institution: Japan Atomic Energy Agency
• Principal Investigator: NISHIKINO Masaharu 独立行政法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究副主幹 (70370450)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: レーザープラズマＸ線 / 軟Ｘ線レーザー / 放射線生物影響 / マイクロビーム

Research Abstract

Techniques for generating high energy bright short-pulse x-rays have been developed with utilizing intense ultrashort laser pulses. X-ray focusing optics has enabled focused x-ray beams of micron spot size in soft x-ray regions. The short duration of laser produced plasma source could be a new source in contrast to conventional x-ray sources in investigating the mechanism of the radiation effect on biological cells. We investigated whether the soft X-ray laser induces the DNA double strand breaks (DSB) and single strand breaks (SSB) in living cell or not. The appearance of DSB induced by soft X-ray laser was significantly different in that induced by a conventional high energy X-ray source. We also demonstrated an efficient extreme ultraviolet source for an X-ray microscopy technique, and developed a grazing angle incident reflection type soft-X-ray microscope using a Fresnel zone plate.

Research Products

• [Journal Article] Development of Soft X-Ray Microscopy Using Fresnel Zone Plate for Observation of Laser-Induced Surface Dynamics (2013)
  • Author(s): M. Nishikino et al.(他7名)
  • Journal Title: Springer Proceedings in Physics (X-Ray Lasers 2012) Volume: Vol. 147 Pages: p.p. 199-202
  • Peer Reviewed
• [Journal Article] Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique (2013)
  • Author(s): M. Nishikino et al.(他12名)
  • Journal Title: Proceedings of SPIE Volume: vol. 8849 Pages: 88490E-1-6
  • Peer Reviewed
• [Presentation] Observation of the surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique (2013)
  • Author(s): Masaharu Nishikino
  • Organizer: The Eighth International Conference on Inertical Fusion Sciences and Applications
  • Place of Presentation: 奈良県立公会堂(奈良)
  • Year and Date: 2013-09-13
• [Presentation] Observation of the nano-scale surface dynamics of femtosecond laser ablation by time-resolved soft x-ray imaging technique (2013)
  • Author(s): M. Nishikino
  • Organizer: SPIE Optics+Photonics (X-Ray Lasers and Coherent X-Ray Sources; Development and Applications X)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-08-27
• [Presentation] プラズマX線レーザーの発生と物質アプレーション (2012)
  • Author(s): 錦野将元
  • Organizer: 2012年応用物理学会秋期学術講演会
  • Place of Presentation: 愛媛大学(愛媛)
  • Year and Date: 2012-09-11
• [Presentation] Development of soft x-ray microscopy using Fresnel zone plate for ibservation of laser-induced surface dynamics (2012)
  • Author(s): Masaharu Nishikino
  • Organizer: International conference on X-ray lasers 2012
  • Place of Presentation: Historical Center of Cordeliers, Paris, France
  • Year and Date: 2012-06-14