2014 Fiscal Year Final Research Report
Development of a novel bioinformatics method to identify novel functional peptides in a genome and experimental verification of their anticancer effects
| Project/Area Number |
24710222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Chiba University |
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Principal Investigator |
TAKAHASHI HIRO 千葉大学, 園芸学研究科, 准教授 (30454367)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | バイオインフォマティクス / 翻訳抑制 / がん |
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| Outline of Final Research Achievements |
The objectives are outlined in the title. Accordingly, we developed a novel bioinformatics method. This method was applicable to various genomes, and the function of the identified peptides was confirmed empirically by a transient in vitro assay. Moreover, we observed in vitro inhibition of growth of a sarcoma, murine sarcoma Sendai (MUSS) by 4E-BP peptides that inhibited the growth of various carcinomas in vitro.
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| Free Research Field |
バイオインフォマティクス
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