2013 Fiscal Year Final Research Report
Molecular mechanisms linking nutritional and metabolic status to neural tube closure
| Project/Area Number |
24770207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 発生・分化 / シグナル伝達 |
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| Research Abstract |
Although epidemiological studies have suggested that defects in neural tube closure are associated with metabolic status, the underlying molecular mechanism(s) remains elusive. We found that the metabolic sensor AMPK is essential for anterior neural tube closure in Xenopus. Our biochemical experiments revealed that a cytoskeleton-regulating protein is an AMPK substrate in vivo. These results suggest the possibility that AMPK links the metabolic sensing pathway to the cytoskeleton-regulating machinery in neural tube closure.
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