2013 Fiscal Year Final Research Report
Analysis of body axis formation of mouse postimplantation development
| Project/Area Number |
24770219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
SHIOI Go 独立行政法人理化学研究所, 発生・再生科学総合研究センター, 専門職研究員 (60391968)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 前後軸形成 / 胚培養 / ライブイメージング / レポーターマウス / 細胞挙動 |
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| Research Abstract |
To reveal the mechanism of the anterior-posterior (A-P) axis formation in a mouse embryo, the expression pattern of head organizer genes have been reexamined. I found that OTX2 gene was asymmetrically expressed from the very beginning of their expression. The gene which makes Otx2 express asymmetrically might have an important role to develop A-P axis. I also established a culture system of mouse embryos for live-imaging experiments. Then, the behavior of each embryonic visceral endoderm cell during the A-P axis formation has been examined by live-imaging experiments. I found some characteristic cell behaviors which remained to be reported.
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