2014 Fiscal Year Final Research Report
The investigation of the birth of methicillin-resistant Staphylococcus aureus (MRSA) by using genome-wide phylogenetic analysis.
| Project/Area Number |
24780298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | MRSA / whole-genome sequencing |
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| Outline of Final Research Achievements |
Methicillin-resistant Staphylococcus (S.) aureus (MRSA) is one of the most important multidrug-resistant pathogen of human and animals. The investigation of the birth of MRSA may contribute to more effective control measures for MRSA. In this study, to elucidate the birth of MRSA, we focus on the animal-borne staphylococci, which harbor the origin of the methicillin-resistant gene and its homologues, and performed the whole-genome sequencing and phylogenetic analysis of them. The results suggest the mobile genetic element encoding methicillin-resistance was composed on the chromosome of the animal-borne staphylococci before the element horizontally transferred to the chromosome of S. aureus.
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| Free Research Field |
獣医学
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