2013 Fiscal Year Final Research Report
Regulatory mechanism of Reelin proteolysis
| Project/Area Number |
24790081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
KOHNO Takao 名古屋市立大学, 薬学研究科(研究院), 助教 (70581742)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | リーリン / プロテアーゼ / プロテオリシス |
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| Research Abstract |
Reelin is a secreted glycoprotein that plays essential roles in the brain formation. Reelin is specifically cleaved at two sites (N-t and C-t site). However, the mechanism and the physiological role of Reelin cleavage is largely unknown. In this study, we determined the N-t cleavage site, and found that N-t cleavage of Reelin plays critical roles in regulating the duration and range of Reelin functions. Furthermore, we identified the protease from supernatant of cultured neurons, and found that this protease is the major protease in charge of Reelin cleavage in embryonic cerebral cortex.
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