2014 Fiscal Year Final Research Report
Regulation by Nectin-like molecules of hemidesmosome disassembly and reorganization
| Project/Area Number |
24790284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
MIZUTANI Kiyohito 神戸大学, 医学(系)研究科(研究院), 講師 (50559177)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ヘミデスモソーム / インテグリン / Necl / Necl-4 / CADM4 / ErbB3 / PTPN13 / 血管内皮細胞 |
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| Outline of Final Research Achievements |
Hemidesmosomes are one of the cell-extracellular matrix junctions. However, the molecular mechanisms that regulate disassembly and reorganization of hemidesmosomes still remain unclear. In this study, we found that 1) Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly and 2) Necl-4 serves as a regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13.
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| Free Research Field |
細胞生物学
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