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2013 Fiscal Year Final Research Report

Analysis of the functional roles of Periplakin in homeostasis

Research Project

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Project/Area Number 24790314
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKyoto University

Principal Investigator

ITO Shinji  京都大学, 医学(系)研究科(研究院), 特定助教 (50362512)

Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsPeriplakin / 肝臓 / 胆汁鬱滞 / 糖代謝
Research Abstract

We sought the functional roles of periplakin in homeostasis. Periplakin-interacting proteins were screened in normal- and cholestatic mouse liver. Several candidates were identified in cholestatic liver. The gene- and protein expression profiles were also examined. The loss of periplakin function influenced on the expressions of several hepatic molecules during cholestasais; however, the difference were highly susceptible to the genetic background and breeding conditions. These results indicate that the roles of periplakin in cholestatic liver might be limited; otherwise, the functional redundancy for periplakin may exist in mouse liver. Interestingly, the fasting blood glucose levels were reproducibly lowered in periplakin-null mice compared to the gender-matched wild-type littermates. Thus, a functional role of periplakin in fasting blood glucose metabolism was suggested.

  • Research Products

    (1 results)

All 2013

All Journal Article (1 results)

  • [Journal Article] Cholestasis induces reversible accumulation of Periplakin in mouse liver2013

    • Author(s)
      Shinji Ito, Junko Satoh, Tsutomu Matsubara, Yatrik M Shah, Sung hoon Ahn, Cherie R Anderson, Jeffrey M Peters, Frank J Gonzalez
    • Journal Title

      BMC Gastroenterology

      Volume: 13 Pages: 116

URL: 

Published: 2015-06-25  

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