2013 Fiscal Year Final Research Report
Analysis of mechanism for causing fulminant infections of Streptococcus pneumoniae
| Project/Area Number |
24790427
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
CHANG BIN 国立感染症研究所, 細菌第一部, 主任研究官 (50370961)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肺炎球菌 / 劇症型肺炎球菌感染症 |
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| Research Abstract |
Streptococcus pneumoniae is a major etiologic agent of otitis media, pneumonia, sepsis, and meningitis. It is rare that the organism causes fulminant infections.
During 1998 to 2013, a total of 22 sporadic fulminant pneumococcal infections were reported to us. In order to reveal the mechanism by which S. pneumoniae causes fulminant disease, pathogenicity of the bacteria was investigated. S. pneumoniae strains isolated from fulminant infections and other type of disease, which showed same serotypes and sequence types, were used to compare pathogenicity in vitro. Survival in human peripheral blood neutrophil, stimulation of platelet activation, effect on the induction of cytokine (IL-6, IL-8, IL-1 beta) of macrophage cell line THP-1 were investigated. But no signification difference between S. pneumoniae isolated from various types could be found. All of these results showed the possibility that the host factor(s) may be important for occurrence of overwhelming pneumococcal infection.
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[Journal Article] Prevalence and risk factors of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children in Japan2013
Author(s)
Masahiro Ueno, Yoshikazu Ishii, Kazuhiro Tateda, Yoshiko Anahara, Akiko Ebata, Masaei Iida, Seiko Inamura, Kahori Takahata, Yoko Suzuki, Bin Chang, Akihito Wada, Minoru Sugita, Taichiro Tanaka, Yuji Nishiwaki
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 66巻
Pages: pp. 22 25
URL
Peer Reviewed
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[Journal Article] Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease2013
Author(s)
Tomohiro Oishi, Naruhiko Ishiwada, Kousaku Matsubara, Junichiro Nishi, Bin Chang, Kazuyo Tamura, Yukihiro Akeda, Toshiaki Ihara, Moon H. Nahm, Kazunori Oishi , the Japanese IPD Study Group
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Journal Title
Vaccine
Volume: 31巻
Pages: pp.845 849
DOI
Peer Reviewed
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