2013 Fiscal Year Final Research Report
Clarifying the mechanism of B cell tolerance by CIN85-mediated BCR regulation
| Project/Area Number |
24790487
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
KOMETANI Kohei 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (50437258)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 免疫寛容 |
|---|
| Research Abstract |
To verify the possibility that adaptor molecule CIN85, which is required for transducing B Cell Receptor (BCR) signalling, have a role in the induction and maintenance of immune tolerance in B cells, I established a below experimental system.
First, I generated B cell specific CIN85-deficient mice using mb1-Cre knock in mice and flox-CIN85 mice. Second, CIN85 B cell specific deficient mice were crossed with mice those have a BCR recognising Hen Egg Lysozyme (HEL) and the mice expressing soluble HEL antigen.
|
Research Products
(3 results)
-
[Journal Article] Repression of Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation2013
Author(s)
Kohei Kometani, Rinako Nakagawa, Ryo Shinnakasu, Tomohiro Kaji, Andrei Rybouchkin, Saya Moriyama, Koji Furukawa, Haruhiko Koseki, Toshitada Takemori, Tomohiro Kurosaki
-
Journal Title
Immunity
Volume: 25巻, vol. 39(1)
Pages: 136-147
DOI
Peer Reviewed
-
-
