2013 Fiscal Year Final Research Report
Application of chronotherapy of antirheumatic drug to perform proper therapy
| Project/Area Number |
24790531
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
TO Hideto 富山大学, 大学院医学薬学研究部(薬学), 教授 (90346809)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 関節リウマチ / メトトレキサート / 時間治療 / 臨床研究 / 生体リズム / 個別化治療 |
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| Research Abstract |
We have performed the randomized double blind controlled trial of chronotherapy against rheumatoid arthritis (RA) patients treated methotrexate (MTX). We divided into two groups of the standard MTX schedule and chronotherapy schedule, in which the dose and number of doses per week were not changed from the standard MTX schedule of each patient but MTX was administered once a day at bedtime. In interim report, the chronotherapy schedule group improved therapeutic effects compared with the standard MTX schedule group. In basic study, we investigated what cytokines and/or transcriptional factors are involved in the formation of 24-hour variations in TNF-alpha levels after the onset of RA using MRL/lpr mice. SAA and TNF-alpha concentrations clearly exhibited 24-hour rhythms with higher levels at the light phase and lower levels at the dark phase after RA crisis. One of the causes of the 24-hour rhythm of TNF-alpha expression in RA may have been clarified by this study.
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Research Products
(15 results)
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[Remarks] 1."からだの時計"が医療を変える、クローズアップ現代, NHK(2012年4月23日)
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[Remarks] 2.ダイエットからがん治療まで!"時計遺伝子"活用術、あさイチ, NHK(2012年5月9日)
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[Remarks] 3.日本時間生物学会 奨励賞「時間薬物療法の臨床応用を目指したトランスレーショナルリサーチ」(2013年11月10日)
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[Remarks] 4.第34回日本臨床薬理学会学術総会優秀演題賞「トトレキサートの少量頻回投薬による関節炎増悪抑制効果への影響」(指導学生受賞)
