2014 Fiscal Year Final Research Report
Investigation of involvement of epigenetic regulation in pathogenic mechanism of indium lung
| Project/Area Number |
24790588
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
|
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| Research Institution | Kochi University |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | インジウム化合物 / 産業医学 / エピジェネティクス / 呼吸器炎症 |
|---|
| Outline of Final Research Achievements |
Intratracheal instillation of indium oxide successfully caused indium lung in mice. Lung tissues of mice with indium lung revealed feature of pulmonary alveolar proteinosis. Comprehensive analyses of gene expression by RNA-Seq exhibited that the markers for interstitial abnormalities were expressed in indium exposed mice group. These results may provide a clue for the therapeutic development of indium lung. The indium mice model developed by intratracheal instillation method contributes the proceeding of future research in indium lung.
|
| Free Research Field |
産業医学
|
