2013 Fiscal Year Final Research Report
Prevalence of serum celiac antibody in Japan
| Project/Area Number |
24790726
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
WATANABE CHIKAKO 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育学部医学科専門課程, 講師 (90365263)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 下部消化管学 / 粘膜免疫 / セリアック病 / グルテン / 過敏性腸症 |
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| Research Abstract |
[Background] Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers. The aim of this study was to examine the current incidence of celiac disease, especially in IBD patients in Japan, where both wheat consumption and incidence of IBD have increased. [Methods] A total of 172 patients with IBD and 190 controls in Japan were screened for serum antibody of tissue transglutaminase and deaminated gliadin peptide. In sero-positive patients, HLA testing and upper gastrointestinal endoscopy with duodenal biopsy was performed.[Conclusion] Despite the increased incidence of IBD and high positivity for serum celiac antibody in Japanese IBD patients, no true-positive celiac disease was noted, suggesting the presence of gluten intolerance in these populations.
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Research Products
(10 results)
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[Journal Article] Prevalence of serum celiac antibody in patients with IBD in Japan2014
Author(s)
Watanabe C, Komoto S, Hokari R, Kurihara C, Okada Y, Hozumi H, Higashiyama M, Sakuraba A, Tomita K, Tsuzuki Y, Kawaguchi A, Nagao S, Ogata S, Miura S
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Journal Title
J. Gastroenterol
Volume: 49(5)
Pages: 825-34
Peer Reviewed
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[Journal Article] Issues associated with the emergence of coeliac disease in the Asia.Pacific region : a working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology2014
Author(s)
2.Makharia GK, Mulder CJ, Goh KL, Ahuja V, Bai JC, Catassi C, Green PH, Gupta SD, Lundin KE, Ramakrishna BS, Rawat R, Sharma H, Sood A, Watanabe C, Gibson PR; World Gastroenterology Organization-Asia Pacific Association of Gastroenterology Working Party on Celiac Disease
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Journal Title
J Gastroenterol Hepatol
Volume: 29(4)
Pages: 666-77
Peer Reviewed
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[Presentation] Prevalence of celiac disease in patients with inflammatory bowel disease : A study from Japan2012
Author(s)
Watanabe C, Hokari R, Kurihara C, Ueda T, Hozumi H, Sato H, Narimatsu K, Okada Y, Sato S, Komoto S, Tomita K, Kawaguchi A, Nagao S, Miura S
Organizer
Disease Week 2012
Place of Presentation
San Diego
Year and Date
20120000
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